Treatment of neuroblastoma with /sup 131/I-metaiodobenzylguanidine

Journal Article · Thu Jan 01 00:00:00 EST 1987 · Med. Pediatr. Oncol.; (United States)

DOI:https://doi.org/10.1002/mpo.2950150417· OSTI ID:5721669

Troncone, L; Riccardi, R; Montemaggi, P; Rufini, V; Lasorella, A; Mastrangelo, R

Seven patients with neuroblastoma (six children and one adult) were treated with therapeutic doses of high specific activity /sup 131/I-metaiodobenzylguanidine (/sup 131/I-MIBG). Six patients were in stage IV and unresponsive to conventional treatment. One patient, in stage III, was treated at diagnosis, an approach never previously reported. Single doses of /sup 131/I-MIBG varying from 70 to 184 mCi split into two parts were administered by slow i.v. infusion (4 to 8 hours) at 2- to 4-day intervals. The following results were obtained in the six evaluable patients: two patients showed transient stabilization of the disease; three had an objective response, with shrinking of the primary tumor and/or regression of the metastatic lesions. Of these three patients, two suffered relapses at 2 and 7 months, respectively, from the first course of MIBG. The third patient, in whom the residual disease almost completely disappeared following MIBG therapy, is still alive in complete remission after autologous bone marrow transplantation with a follow-up of 14 months. The single patient treated at diagnosis showed a dramatic response to a relatively low dosage of MIBG, with histologically proved disappearance of the tumor mass. Our data indicate that MIBG may be useful in the treatment of neuroblastoma unresponsive to conventional chemotherapy. The complete response observed in the patient treated at diagnosis suggests that the full potentiality of MIBG therapy should be explored in untreated patients.

• Research Organization: Catholic Univ., Rome, Italy
• OSTI ID: 5721669
• Journal Information: Med. Pediatr. Oncol.; (United States), Vol. 15:4
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
NEOPLASMS
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DRUGS
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IODINE 131
METASTASES
PATIENTS
AGE GROUPS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
DAYS LIVING RADIOISOTOPES
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550604* - Medicine- Unsealed Radionuclides in Therapy- (1980-)