Administered dose and tumor dose of bleomycin labeled with cobalt-57 in mice and men

Journal Article · Thu Nov 01 04:00:00 EST 1990 · Journal of Nuclear Medicine; (USA)

OSTI ID:6321629

Front, D; Israel, O; Iosilevsky, G; Even-Sapir, E; Ben-Haim, S; Frenkel, A; Ber, R; Milstein, D; Kolodny, G M ^[1]

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1. Rambam Medical Center, Haifa (Israel)

Tumor concentrations of the chemotherapeutic drug, bleomycin, labeled with cobalt-57 (Co-bleo) were compared in mouse tumor models and in human lung tumors using quantitative single-photon emission computed tomography. Drug concentrations in histologically similar human tumors showed marked variability for the same injected dose (ID). Small cell carcinomas showed concentrations between 1.09 and 8.85 %ID/cc x 10(-3) while non-small cell lung tumors showed a concentration variation between 0.36 and 6.75 %ID/cc x 10(-3). In contrast to the situation in human tumors, uptake in mouse tumors showed only slight variability in animals with the same tumor model. EMT-6 tumors in mice showed at 6 hr significantly higher uptake of Co-bleo (p less than 0.001) and significantly higher tumor-to-lung ratio (p less than 0.001) when compared to murine fibrosarcomas. The EMT-6 tumors in contrast to the fibrosarcomas responded to bleomycin treatment in a dose dependent manner. The results indicate that while in mice the tumor dose closely follows the administered dose, in humans, the tumor dose and the tumor-to-lung ratio in the individual patient cannot be predicted from the administered dose.

• OSTI ID: 6321629
• Journal Information: Journal of Nuclear Medicine; (USA), Journal Name: Journal of Nuclear Medicine; (USA) Vol. 31:11; ISSN 0161-5505; ISSN JNMEA
• Country of Publication: United States
• Language: English

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62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMALS
ANTI-INFECTIVE AGENTS
ANTIBIOTICS
ANTIMITOTIC DRUGS
ANTINEOPLASTIC DRUGS
BETA DECAY RADIOISOTOPES
BLEOMYCIN
BODY
CARCINOMAS
COBALT 57
COBALT ISOTOPES
COMBINED THERAPY
COMPARATIVE EVALUATIONS
COMPUTERIZED TOMOGRAPHY
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DISEASES
DOSES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
EMISSION COMPUTED TOMOGRAPHY
INTERMEDIATE MASS NUCLEI
ISOTOPES
LUNGS
MAMMALS
MAN
MICE
NEOPLASMS
NUCLEI
ODD-EVEN NUCLEI
ORGANS
PRIMATES
RADIATION DOSES
RADIOISOTOPES
RESPIRATORY SYSTEM
RODENTS
SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY
THERAPY
TOMOGRAPHY
UPTAKE
VERTEBRATES