SPECT quantitation of cobalt-57 bleomycin delivery to human brain tumors

Journal Article · Mon Feb 01 04:00:00 EST 1988 · J. Nucl. Med.; (United States)

OSTI ID:5172908

Front, D; Israel, O; Iosilevsky, G; Even-Sapir, E; Frenkel, A; Kolodny, G M; Feinsod, M

A newly developed and validated noninvasive quantitative SPECT method was used to measure the in vivo uptake of (/sup 57/Co)bleomycin (Co-bleo) in 13 human brain tumors and the uptake of (/sup 99m/Tc)glucoheptonate (GH) in 23 brain tumors. Significant differences in tumor uptake were found. The tumor concentration over time, the tumor to blood radioactivity at 30 min and the tumor cumulative concentration of radioactivity showed marked differences even between tumors with the same histology. Only a weak correlation was found between tumor concentration of Co-bleo and of GH. Therefore, a simple imaging agent such as GH cannot, at the present time, serve as an indicator of individual tumor uptake and further experience with other agents is still necessary. Contrary to the generally held view, no correlation was found between the concentration of drug in the blood and its tumor concentration. It is suggested, therefore, that the level of a drug in the blood cannot be used as a criterion of the amount that will penetrate the tumor. Direct SPECT measurement of the concentration of the drug in the tumor itself should be performed. The bioavailability of a drug is critical in order for it to exert it tumoricidal effect. The results, showing marked differences in uptake between brain tumors, suggest that before chemotherapy is administered, uptake of the chemotherapeutic drug in the individual tumor to be treated should be assessed and comparisons should be made between the uptake of a series of drugs to determine which drug would be most efficacious on the basis of its uptake as well as its tumor cell killing potential

• Research Organization: Rambam Medical Center, Haifa (Israel)
• OSTI ID: 5172908
• Journal Information: J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 29:2; ISSN JNMEA
• Country of Publication: United States
• Language: English

Related Subjects

550600 -- Medicine
550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMALS
ANTI-INFECTIVE AGENTS
ANTIBIOTICS
ANTIMITOTIC DRUGS
ANTINEOPLASTIC DRUGS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL AVAILABILITY
BIOLOGICAL MATERIALS
BLEOMYCIN
BLOOD
BODY
BODY FLUIDS
BRAIN
CELL KILLING
CENTRAL NERVOUS SYSTEM
CHEMOTHERAPY
COBALT 57
COBALT ISOTOPES
COMPUTERIZED TOMOGRAPHY
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DISEASES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
EMISSION COMPUTED TOMOGRAPHY
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
MAN
MATERIALS
NEOPLASMS
NERVOUS SYSTEM
NUCLEI
ODD-EVEN NUCLEI
ORGANS
PRIMATES
RADIOISOTOPES
SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY
TECHNETIUM 99
TECHNETIUM ISOTOPES
THERAPY
TOMOGRAPHY
UPTAKE
VERTEBRATES
YEARS LIVING RADIOISOTOPES