Interaction of ethanol and mercury body burden in the mouse
The interaction of ethanol with mercury in the body resulting in increased exhalation of the metal was studied in the mouse. A persistent elimination of the metal in the breath was demonstrated after single, sublethal (<1 mgHg/Kg body weight) exposures to mercury vapor (Hg/sup 0/) or mercury II chloride (HgCl/sub 2/). The amount of mercury exhaled per unit time was enhanced by oral or parenteral administration of ethanol solutions. These modifications were investigated in dose-response studies in which the drug was administered in doses ranging from 0.2g to 5.5g/Kg to mice pretreated with mercury. The EC/sub 50/ for blood ethanol with respect to mercury exhalation was determined to be approximately 200 mg/dl corresponding to an output rate of approximately 0.1% of the simultaneous body burden in 30 min several days after mercury. A hypothesis that mercury expired by these animals was proportional to the body burden after mercury administration was addressed in experiments whereby mice given one of several doses of mercuric chloride (0.16 to 500 ..mu..g/Kg) were monitored for pulmonary mercury elimination for a fifteen day period. The high correlation obtained between the amount of mercury exhaled in a standard time period and the body burden by group indicated that breath sampling could be applied as an indicator of the mercury body burden which may not be limited to the mouse.
- Research Organization:
- Univ. of Rochester, NY (United States)
- DOE Contract Number:
- EY-76-C-02-3490
- OSTI ID:
- 6314847
- Report Number(s):
- UR-3490-1575
- Resource Relation:
- Other Information: Thesis
- Country of Publication:
- United States
- Language:
- English
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BODY BURDEN
MEASURING METHODS
ETHANOL
BIOLOGICAL EFFECTS
MERCURY
EXHALATION
ACUTE EXPOSURE
AEROSOLS
BREATH
EXPERIMENTAL DATA
EXPOSURE CHAMBERS
GRAPHS
INHALATION
INTRAPERITONEAL INJECTION
ISOLATED VALUES
MERCURY 203
MERCURY CHLORIDES
METHYLMERCURY
MICE
SAMPLING
TRACER TECHNIQUES
ALCOHOLS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
CHLORIDES
CHLORINE COMPOUNDS
CLEARANCE
COLLOIDS
DATA
DATA FORMS
DAYS LIVING RADIOISOTOPES
DISPERSIONS
ELEMENTS
EVEN-ODD NUCLEI
EXCRETION
HALIDES
HALOGEN COMPOUNDS
HEAVY NUCLEI
HYDROXY COMPOUNDS
INFORMATION
INJECTION
INTAKE
ISOTOPE APPLICATIONS
ISOTOPES
MAMMALS
MERCURY COMPOUNDS
MERCURY HALIDES
MERCURY ISOTOPES
METALS
NUCLEI
NUMERICAL DATA
ORGANIC COMPOUNDS
ORGANIC MERCURY COMPOUNDS
RADIOISOTOPES
RODENTS
SOLS
VERTEBRATES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)