Chemical class fractionation of fossil-derived materials for biological testing
Chemical fractionation of whole products and by-products from synthetic fuel production affords a logical first step in the evaluation of these materials for biological activity and the subsequent prediction of health hazards. Aliphatic and aromatic hydrocarbons, along with smaller amounts of heteroatomic species, constitute the bulk of all crude product materials and define a primary class separation need. Subfractionation of these fractions can lead to identification of bioactive components. Aliphatics are separated from the entire sample by a simple liquid chromatographic elution scheme. Aromatic compounds can be isolated by a cyclohexane-dimethylsulfoxide solvent partitioning scheme. A Sephadex LH-20 gel separation scheme appears feasible for the fractionation of crude liquids into aliphatic-aromatic, lipophilic-hydrophilic, polymeric, and hydrogen bonding classes of compounds. 5 figures, 2 tables.
- Research Organization:
- Oak Ridge National Lab., TN
- OSTI ID:
- 6312380
- Journal Information:
- Adv. Chem. Ser.; (United States), Vol. 170
- Country of Publication:
- United States
- Language:
- English
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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
01 COAL, LIGNITE, AND PEAT
ALKANES
BIOASSAY
BIOLOGICAL EFFECTS
CHEMICAL REACTION YIELD
POLYCYCLIC AROMATIC HYDROCARBONS
SYNTHETIC FUELS
CYCLOHEXANE
DMSO
FRACTIONATION
HEALTH HAZARDS
LIQUID COLUMN CHROMATOGRAPHY
SEPARATION PROCESSES
SOLVENT EXTRACTION
AROMATICS
CHROMATOGRAPHY
CYCLOALKANES
EXTRACTION
FUELS
HAZARDS
HYDROCARBONS
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
SULFOXIDES
YIELDS
040700* - Oil Shales & Tar Sands- Health & Safety
040900 - Oil Shales & Tar Sands- Waste management
560300 - Chemicals Metabolism & Toxicology
016000 - Coal
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