Chemical class fractionation of fossil-derived materials for biological testing
Chemical fractionation of whole products and by-products from synthetic fuel production affords a logical first step in the evaluation of these materials for biological activity and the subsequent prediction of health hazards. Aliphatic and aromatic hydrocarbons, along with smaller amounts of heteroatomic species, constitute the bulk of all crude product materials and define a primary class separation need. Subfractionation of these fractions can lead to identification of bioactive components. Aliphatics are separated from the entire sample by a simple liquid chromatographic elution scheme. Aromatic compounds can be isolated by a cyclohexane-dimethylsulfoxide solvent partitioning scheme. A Sephadex LH-20 gel separation scheme appears feasible for the fractionation of crude liquids into aliphatic-aromatic, lipophilic-hydrophilic, polymeric, and hydrogen bonding classes of compounds. 5 figures, 2 tables.
- Research Organization:
- Oak Ridge National Lab., TN
- OSTI ID:
- 6312380
- Journal Information:
- Adv. Chem. Ser.; (United States), Journal Name: Adv. Chem. Ser.; (United States) Vol. 170; ISSN ADCSA
- Country of Publication:
- United States
- Language:
- English
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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKANES
AROMATICS
BIOASSAY
BIOLOGICAL EFFECTS
CHEMICAL REACTION YIELD
CHROMATOGRAPHY
CYCLOALKANES
CYCLOHEXANE
DMSO
EXTRACTION
FRACTIONATION
FUELS
HAZARDS
HEALTH HAZARDS
HYDROCARBONS
LIQUID COLUMN CHROMATOGRAPHY
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
POLYCYCLIC AROMATIC HYDROCARBONS
SEPARATION PROCESSES
SOLVENT EXTRACTION
SULFOXIDES
SYNTHETIC FUELS
YIELDS