Synthesis of new prophylactic antiradiation drugs. Progress report no. 2 (annual), 1 Aug 80-31 Jul 81

Technical Report · Sat Aug 01 04:00:00 EDT 1981

OSTI ID:6309978

Bauer, L

This report presents details of the work done on the project (covered) during the last 12 months. Approaches to the synthesis of a number of 3-aryl l-(omega-aminoalkyl) adamantanes is described. Their final incorporation in the preparation of N-(adamantylalkyl) alpha-mercapto acetamidines, and derivatives, as potential antiradiation drugs is projected. The report divided into two major sections. The first deals with the preparation of 1,3-bis(2-aminoethyl) adamantane and its conversion to the disulfide of 1,3-bis(2-(mercaptomethylcarboxamidino) ethyl)-adamantane. The next section describes the synthesis of some 3-aryl-l-adamantanecarboxylic and acetic acids, 12 (n=0 or 1, respectively). These are the vital precursors needed for the synthesis of the essential 3-aryl (l-adamantylmethyl and ethylamines), 11, which will be a part of the N-substituent of the target alpha-mercaptoacetamidines and derivatives.

• Research Organization: Illinois Univ., Chicago (USA). Dept. of Medicinal Chemistry
• OSTI ID: 6309978
• Report Number(s): AD-A-122649/7
• Country of Publication: United States
• Language: English

Related Subjects

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
400301* -- Organic Chemistry-- Chemical & Physicochemical Properties-- (-1987)
560151 -- Radiation Effects on Animals-- Man
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ADAMANTANE
ALKANES
CHEMICAL PREPARATION
CYCLOALKANES
DRUGS
HYDROCARBONS
MOLECULAR STRUCTURE
ORGANIC COMPOUNDS
RADIOPROTECTIVE SUBSTANCES
SYNTHESIS