Synthesis of new prophylactic antiradiation drugs. Annual report, 1 August 1982-31 July 1983

Technical Report · Mon Aug 01 04:00:00 EDT 1983

OSTI ID:5943831

Bauer, L

This report is divided into four (4) major sections. Each section addresses a phase of the syntheses of adamantyl aryl alkylamines where the amine is incorported into an N-substituted 2-mercaptoacetamidine, or a derivative of the sulfide function. The first part describes the efforts in the 1-aryl-3-adamantyl-methylamine series where the aryl group is 2-thienyl. The next section is devoted to the practical approaches to the synthesis of 1-aryl-2-adamantylalkyl-amines. The work culminates in the preparation of the first member, namely, 1-phenyl-2-adamantylmethylamine. The third section describes some preliminary work on the preparation of 1-aryl-4-adamantylalkylamines. And, the last section reports the synthesis of 4-(1-adamantyl)benzylamines and its conversion to the disulfide based on N-(4-(1-adamantyl)benzyl)-2-mercaptoacetamidine.

• Research Organization: Illinois Univ., Chicago (USA). Dept. of Medicinal Chemistry
• OSTI ID: 5943831
• Report Number(s): AD-A-148649/7/XAB
• Country of Publication: United States
• Language: English

Related Subjects

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
400301 -- Organic Chemistry-- Chemical & Physicochemical Properties-- (-1987)
560100* -- Biomedical Sciences
Applied Studies-- Radiation Effects
560300 -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
CHEMICAL REACTIONS
DRUGS
MAMMALS
MICE
MOLECULAR STRUCTURE
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
RADIOPROTECTIVE SUBSTANCES
RODENTS
SYNTHESIS
TOXICITY
VERTEBRATES