Effects of antidepressant drugs on histamine-H/sub 1/ receptors in the brain

Journal Article · Sun Feb 05 23:00:00 EST 1984 · Life Sci.; (United States)

DOI:https://doi.org/10.1016/0024-3205(84)90494-6· OSTI ID:6304590

Hall, H; Oegren, S O

The histamine-H/sub 1/ receptor blocking properties of a number of structurally different antidepressant drugs have been evaluated using a /sup 3/H-mepyramine binding assay and a guinea-pig ileum preparation. The tricyclic antidepressants all inhibited the histamine-H/sub 1/ receptor. Some newer antidepressant drugs, such as zimeldine and nomifensine were devoid of activity while others, such as iprindole and mianserin were very potent. It is concluded that antagonistic effects on the histamine-H/sub 1/ receptor is not associated with the therapeutic efficacy in depression, but may contribute to the sedative effects of the antidepressant drugs.

• Research Organization: Research and Development Lab., Soedertaelje, Sweden
• OSTI ID: 6304590
• Journal Information: Life Sci.; (United States), Journal Name: Life Sci.; (United States) Vol. 34:6; ISSN LIFSA
• Country of Publication: United States
• Language: English

Related Subjects

550201* -- Biochemistry-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
AMINES
ANIMALS
ANTIDEPRESSANTS
ANTIHISTAMINICS
AZOLES
BODY
BRAIN
CENTRAL NERVOUS SYSTEM
CENTRAL NERVOUS SYSTEM AGENTS
CHEMICAL BONDS
DIGESTIVE SYSTEM
DRUGS
GASTROINTESTINAL TRACT
GUINEA PIGS
HETEROCYCLIC COMPOUNDS
HISTAMINE
IMIDAZOLES
INTESTINES
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
MAMMALS
NERVOUS SYSTEM
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PSYCHOTROPIC DRUGS
RADIOASSAY
RECEPTORS
RODENTS
SMALL INTESTINE
TRACER TECHNIQUES
TRITIUM COMPOUNDS
VERTEBRATES