In vitro histamine H/sub 2/-antagonist activity of the novel compound HUK 978

Journal Article · Sun Nov 03 23:00:00 EST 1985 · Life Sci.; (United States)

DOI:https://doi.org/10.1016/0024-3205(85)90299-1· OSTI ID:5021833

Coombes, J D; Norris, D B; Rising, T J; Ross, B C; Steward, A

Histamine stimulated adenylate cyclase from guinea-pig fundic mucosa and /sup 3/H-tiotidine binding in guinea-pig cerebral cortex were used to assess the in-vitro histamine H/sub 2/-activity of the novel H/sub 2/-antagonist HUK 978. The results showed that HUK 978 was a more potent H/sub 2/-antagonist than either cimetidine or ranitidine. HUK 978 was also shown to be devoid of activity at the histamine H-/sub 1/-receptor, the muscarinic receptor and the ..cap alpha.. and ..beta..-adrenergic receptors.

• Research Organization: Hoechst Pharmaceutical Research Lab., Milton Keynes, England
• OSTI ID: 5021833
• Journal Information: Life Sci.; (United States), Journal Name: Life Sci.; (United States) Vol. 37:18; ISSN LIFSA
• Country of Publication: United States
• Language: English

Related Subjects

550201* -- Biochemistry-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
AMINES
ANIMALS
AZOLES
BODY
BRAIN
CENTRAL NERVOUS SYSTEM
CEREBRAL CORTEX
CEREBRUM
CHEMICAL BONDS
CYCLASES
ENZYME ACTIVITY
ENZYMES
GUINEA PIGS
HETEROCYCLIC COMPOUNDS
HISTAMINE
IMIDAZOLES
IN VITRO
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
LYASES
MAMMALS
NERVOUS SYSTEM
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
RECEPTORS
RODENTS
TRACER TECHNIQUES
TRITIUM COMPOUNDS
VERTEBRATES