Effects of low-level radiation upon the hematopoietic steam cell: implications for leukemogenesis

Technical Report · Sat Jan 01 04:00:00 EST 1983

DOI:https://doi.org/10.2172/6300559· OSTI ID:6300559

Cronkite, E P; Bond, V P; Carsten, A L; Miller, M E; Bullis, J E

These studies have addressed firstly the effect of single small doses of x-ray upon murine hematopoietic stem cells to obtain a better estimate of the D/sub q/. It is small, of the order of 20 rads. Secondly, a dose fractionation schedule tht does not kill or perturb the kinetics of hemopoietic cell proliferation was sought in order to investigate the leukemogenic potential of low level radiation upon an unperturbed hemopoietic system. The studies reported herein show tht 1.25 rads every other day decrease the CFU-S content of bone marrow by the time 40 rads are accumulated. Studies on the effect of 0.5, 1.0, 2.0, and 3.0 rads 3 times per week are under way. Two rads 3 times per week produced a modest decrease in CFU-S content of bone marrow after an accumulation of 68 rads. With 3.0 rads 3 times per week an accumulation of 102 rads produces a significant decrease in CFU-S content of bone marrow. Dose fractionation at 0.5 and 1.0 rad 3 times per week has not produced a CFU-S depression after accumulation of 17 and 34 rads. Radiation leukemogenesis studies published to date have utilized single doses and chronic exposure schedules that probably have significantly perturbed the kinetics of hematopoietic stem cells. Whether radiation will produce leukemia in animal models with dose schedules that do not perturb kinetics of hematopoietic stem cells remains to be seen.

• Research Organization: Brookhaven National Lab., Upton, NY (USA)
• DOE Contract Number: AC02-76CH00016
• OSTI ID: 6300559
• Report Number(s): BNL-32840; CONF-830450-1; ON: DE83010855
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMAL TISSUES
ANIMALS
BODY
BONE MARROW
CARCINOGENESIS
CELL PROLIFERATION
DATA
DOSE-RESPONSE RELATIONSHIPS
ELECTROMAGNETIC RADIATION
EXPERIMENTAL DATA
FRACTIONATED IRRADIATION
HEMATOPOIETIC SYSTEM
INFORMATION
IONIZING RADIATIONS
IRRADIATION
LEUKEMOGENESIS
MAMMALS
MICE
NUMERICAL DATA
ORGANS
PATHOGENESIS
RADIATIONS
RODENTS
SOMATIC CELLS
STEM CELLS
TISSUES
VERTEBRATES
X RADIATION