Efficient microscale preparation of tin-117m-tin tetrachloride-a pivotal intermediate for the synthesis of tin-117m-labeled radiopharmaceuticals

Conference · Mon Jan 01 04:00:00 EST 1979

OSTI ID:6298932

Woo, D. V.; Knapp, Jr., F. F.; Butler, T. A.; Callahan, A. P.

A microscale technique has been developed for the preparation of /sup 117m/SnCl/sub 4/. The radiolabeled tin tetrachloride is an important intermediate for the synthesis of /sup 117m/Sn-labeled organic radiopharmaceuticals. The flow-through system involves high temperature chlorination of metallic /sup 117m/Sn with subsequent cryogenic collection of the /sup 117m/SnCl/sub 4/ in a special reaction vessel. This vessel can then be used for the conversion of the tin tetrachloride to various useful intermediates. The reactions that have been studied include the formation of tetraalkyl and tetraaryltin compounds by reaction of SnCl/sub 4/ with Grignard or alkyl and aryl lithium reagents (SnCl/sub 4/ ..-->.. R/sub 4/Sn or Ar/sub 4/Sn). In addition, by stoichiometric control, the comproportionation of SnCl/sub 4/ with tetramethyltin can yield any one of the mixed methylchlorotin intermediates, MeSnCl/sub 3/, Me/sub 2/SnCl/sub 2/, or Me/sub 3/SnCl. These products are important intermediates for the preparation of /sup 117m/Sn-labeled steroids, fatty acids, amino acids, barbituates, and a variety of other potentially useful agents.

• Research Organization: Oak Ridge National Lab., TN (USA)
• Sponsoring Organization: USDOE Office of Environment, Safety and Health (EH)
• DOE Contract Number: W-7405-ENG-26
• OSTI ID: 6298932
• Report Number(s): CONF-790321--2
• Country of Publication: United States
• Language: English

Related Subjects

38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
400702* -- Radiochemistry & Nuclear Chemistry-- Properties of Radioactive Materials
550601 -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
AMINO ACIDS
AZINES
BARBITURATES
CARBOXYLIC ACIDS
CHEMICAL PREPARATION
CHEMISTRY
CHLORIDES
CHLORINE COMPOUNDS
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC USES
DRUGS
EVEN-ODD NUCLEI
HALIDES
HALOGEN COMPOUNDS
HETEROCYCLIC COMPOUNDS
HYPNOTICS AND SEDATIVES
INTERMEDIATE MASS NUCLEI
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
LABELLING
MEDICINE
NUCLEAR MEDICINE
NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
PYRIMIDINES
RADIOACTIVE MATERIALS
RADIOCHEMISTRY
RADIOISOTOPES
RADIOPHARMACEUTICALS
STABLE ISOTOPES
STEROIDS
SYNTHESIS
TIN 117
TIN CHLORIDES
TIN COMPOUNDS
TIN HALIDES
TIN ISOTOPES
USES