Effect of short-term fasting on lipolytic responsiveness in normal and obese human subjects
In this study the rate of lipolysis (fatty acid and glycerol release into blood) has been quantified in both normal weight and obese volunteers after both 15 and 87 h of fasting. In each study, the basal rate and subsequent response to epinephrine infusion were determined. The rate of appearance (R/sub a/) of free fatty acids (FFA) and glycerol were quantified by infusion of (1- TC)palmitate and D-5-glycerol, respectively. Substrate flux rates per unit of body fat mass and lean body mass were calculated from total body water measurements using H2 YO dilution. In normal volunteers, the basal R/sub a/ FFA and R/sub a/ glycerol rose markedly with 87 h of fasting, whereas the increases were more modest in the obese subjects. However, the rate of mobilization of fat, in relation to the lean body mass, was higher in the obese subjects than in the normal subjects after 15 h of fasting, and the values were similar in both groups after 87 h of fasting. There was an increased lipolytic response to epinephrine after fasting in both groups. This increased sensitivity may have resulted from the enhancement of fatty acid-triglyceride substrate cycling that occurred after fasting.
- Research Organization:
- Univ. of Texas Medical Branch, Galveston
- OSTI ID:
- 6295349
- Journal Information:
- Am. J. Physiol.; (United States), Journal Name: Am. J. Physiol.; (United States) Vol. 252:2; ISSN AJPHA
- Country of Publication:
- United States
- Language:
- English
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59 BASIC BIOLOGICAL SCIENCES
ADRENAL HORMONES
ADRENALINE
ALCOHOLS
ANIMALS
AUTONOMIC NERVOUS SYSTEM AGENTS
CARBON 14 COMPOUNDS
CARBOXYLIC ACIDS
CARDIOTONICS
CARDIOVASCULAR AGENTS
CHEMICAL REACTIONS
CORTICOSTEROIDS
DECOMPOSITION
DISEASES
DRUGS
EVEN-EVEN NUCLEI
FASTING
GLUCOCORTICOIDS
GLYCEROL
HEXADECANOIC ACID
HORMONES
HYDROCORTISONE
HYDROGEN COMPOUNDS
HYDROLYSIS
HYDROXY COMPOUNDS
INSULIN
ISOTOPES
KETONES
LABELLED COMPOUNDS
LIGHT NUCLEI
LIPIDS
LYSIS
MAMMALS
MAN
METABOLIC DISEASES
METABOLISM
MONOCARBOXYLIC ACIDS
NEUROREGULATORS
NORADRENALINE
NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
OXYGEN 18
OXYGEN COMPOUNDS
OXYGEN ISOTOPES
PEPTIDE HORMONES
PHYSIOLOGY
PREGNANES
PRIMATES
SOLVOLYSIS
STABLE ISOTOPES
STEROID HORMONES
STEROIDS
SYMPATHOMIMETICS
VERTEBRATES
WATER