Transplantation tolerance after total lymphoid irradiation

Journal Article · Thu Mar 01 04:00:00 EST 1979 · Transplant. Proc.; (United States)

OSTI ID:6294399

Strober, S; Slavin, S; Fuks, Z; Kaplan, H S; Gottlieb, M; Bieber, C; Hoppe, R T; Grumet, F C

We have presented an animal model of tissue transplantation tolerance using the unusual effects of TLI on the immune system. The application of TLI to bone marrow and whole-organ transplantation in humans merits further study, since TLI offers several advantages over presently used therapeutic modalities. Current regimens used to prepare patients for marrow transplantation are lethal in the absence of allogeneic marrow engraftment, and marrow donors are restricted to HLA-matched siblings due to the danger of GHVD. On the other hand, TLI is a nonlethal procedure that has been used successfully in animals to transplant allogeneic marrow from unmatched donors without the development of GHVD. Thus, TLI might allow for marrow transplantation in all patients with a single sibling, whereas conventional procedures are feasible in only one of four such cases (probability of finding a single HLA-matched sibling). In addition, the induction of transplantation tolerance with TLI would obviate the requirement for the use of maintenance immunosuppressive drugs after whole-organ transplantation. Systemic infections associated with the use of these drugs currently account for the majority of deaths in heart transplant patients. Serious infectious complications associated with TLI are rare; thus this therapeutic regimen may offer considerable improvement in the long-term survival of organ graft recipients as compared to that presently obtained with immunosuppressive drugs.

• Research Organization: Stanford Univ., CA
• OSTI ID: 6294399
• Journal Information: Transplant. Proc.; (United States), Journal Name: Transplant. Proc.; (United States) Vol. 11:1; ISSN TICPB
• Country of Publication: United States
• Language: English

Related Subjects

560151* -- Radiation Effects on Animals-- Man
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
BONE MARROW
CONNECTIVE TISSUE CELLS
DATA
DATA FORMS
DISEASES
DOGS
EXPERIMENTAL DATA
HEMATOPOIETIC SYSTEM
HODGKINS DISEASE
IMMUNE REACTIONS
IMMUNOSUPPRESSION
INFORMATION
ISOLATED VALUES
KIDNEYS
LEUKOCYTES
LYMPHATIC SYSTEM
LYMPHOCYTES
LYMPHOMAS
MAMMALS
MEDICINE
MICE
NEOPLASMS
NUCLEAR MEDICINE
NUMERICAL DATA
ORGANS
PATIENTS
RADIATION EFFECTS
RADIOLOGY
RADIOTHERAPY
RODENTS
SKIN
SOMATIC CELLS
THERAPY
TISSUES
TRANSPLANTS
VERTEBRATES