Transplantation of bone marrow in outbred dogs without graft-versus-host disease using total lymphoid irradiation

Journal Article · Thu Feb 01 04:00:00 EST 1979 · Transplantation; (United States)

OSTI ID:6179616

Slavin, S; Gottlieb, M; Strober, S; Bieber, C; Hoppe, R; Kaplan, H S; Grumet, F C

The experimental findings reported here confirm and extend our earlier studies which show that preparation of adult mice and rats with TLI allows allogeneic marrow engraftment without GVHD. The immunological mechanisms responsible for the absence of GVHD is unclear. Unlike the presently used recipient treatment regimens, TLI allows for the use of unmatched marrow and obviates the use of post-transplant immunosuppressive therapy. Achievement of marrow engraftment without GVHD in large outbred animals indicates that this technique merits further investigation as a potential tool in marrow transplantation in humans.

• Research Organization: Stanford Univ. School of Medicine, CA
• OSTI ID: 6179616
• Journal Information: Transplantation; (United States), Journal Name: Transplantation; (United States) Vol. 27:2; ISSN TRPLA
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
BONE MARROW
BONE MARROW CELLS
CONNECTIVE TISSUE CELLS
DATA
DATA FORMS
DOGS
EXPERIMENTAL DATA
GRAFT-HOST REACTION
GRAPHS
HEMATOPOIETIC SYSTEM
IMMUNE REACTIONS
INFORMATION
ISOLATED VALUES
KARYOTYPE
LEUKOCYTES
LYMPHATIC SYSTEM
LYMPHOCYTES
MAMMALS
NUMERICAL DATA
ORGANS
RADIATION EFFECTS
RADIATIONS
SOMATIC CELLS
TISSUES
TRANSPLANTS
VERTEBRATES