Skip to main content
OSTI.GOVU.S. Department of Energy Office of Scientific and Technical Information
U.S. Department of Energy
Office of Scientific and Technical Information
 

Long-term effects of cranial irradiation on endocrine function in children with brain tumors. A prospective study

Journal Article · · Cancer (Philadelphia); (United States)
; ; ; ; ; ;
This study prospectively evaluated the endocrine function of 11 children treated with cranial irradiation (CRT) for brain tumors. All tumors were remote from the hypothalamic-pituitary axis. Children were studied before treatment and at 3, 6, and 12 months after the completion of CRT. T4, thyroid-stimulating hormone, prolactin, plasma cortisol, and urinary follicle-stimulating hormone and luteinizing hormone values were normal before and after treatment in all patients. Growth hormone (GH) deficiency was identified in 0 of 7 patients before treatment, in 2 of 7 patients 3 months post-CRT, in 9 of 11 patients 6 months post-CRT, and in 7 of 8 patients 12 months post-CRT. Growth deceleration was identified in five of seven prepubertal patients. GH deficiency is an extremely common sequelae of CRT, beginning as early as 3 months after the completion of CRT. The deficit is progressive over time.
OSTI ID:
6293067
Journal Information:
Cancer (Philadelphia); (United States), Journal Name: Cancer (Philadelphia); (United States) Vol. 9; ISSN CANCA
Country of Publication:
United States
Language:
English

Similar Records

Long-term effects of treatment on endocrine function in children with brain tumors
Journal Article · Mon Oct 31 23:00:00 EST 1983 · Ann. Neurol.; (United States) · OSTI ID:6847710
Effects of external radiation therapy for cancer of the prostate on the serum concentrations of testosterone, follicle-stimulating hormone, luteinizing hormone and prolactin
Journal Article · Mon Aug 01 00:00:00 EDT 1983 · J. Urol.; (United States) · OSTI ID:5671425
Evaluation of growth hormone release and human growth hormone treatment in children with cranial irradiation-associated short stature
Journal Article · Tue Jan 31 23:00:00 EST 1984 · J. Pediatr.; (United States) · OSTI ID:6723199

Related Subjects

550603 -- Medicine-- External Radiation in Therapy-- (1980-)
560151* -- Radiation Effects on Animals-- Man
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ADRENAL HORMONES
AGE GROUPS
AMINO ACIDS
ARGININE
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BRAIN
CARBOXYLIC ACIDS
CENTRAL NERVOUS SYSTEM
CHILDREN
CORTICOSTEROIDS
ENDOCRINE GLANDS
GLANDS
GLUCOCORTICOIDS
GONADOTROPINS
HORMONES
HYDROCORTISONE
HYDROXY COMPOUNDS
INJURIES
INSULIN
KETONES
LH
LTH
MEDICINE
NERVOUS SYSTEM
NUCLEAR MEDICINE
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC IODINE COMPOUNDS
ORGANS
PEPTIDE HORMONES
PITUITARY HORMONES
PREGNANES
RADIATION EFFECTS
RADIATION INJURIES
RADIOLOGY
RADIOTHERAPY
SIDE EFFECTS
STEROID HORMONES
STEROIDS
STH
THERAPY
THYROID HORMONES
THYROXINE
TSH