Lack of effect of deferoxamine, dimethyl sulfoxide, and catalase on monocrotaline pyrrole pulmonary injury
Journal Article
·
· J. Toxicol. Environ. Health; (United States)
Monocrotaline pyrrole (MCTP) is a reactive metabolite of the pyrrolizidine alkaloid monocrotaline. MCTP given intravenously to rats causes pulmonary hypertension and right ventricular hypertrophy. Lesions in lungs after MCTP treatment contain macrophages and neutrophils, which may contribute to the damage by generation of reactive oxygen metabolites. Rats were treated with MCTP and agents known to protect against oxygen radical-mediated damage in acute models of neutrophil-dependent lung injury. Rats received MCTP and deferoxamine mesylate (DF), dimethyl sulfoxide (DMSO), or polyethylene glycol-coupled catalase (PEG-CAT). MCTP/vehicle-treated controls developed lung injury manifested as increased lung weight, release of lactate dehydrogenase into the airway, and sequestration of SVI-labeled bovine serum albumin in the lungs. Cotreatment of rats with DF, DMSO, or PEG-CAT did not protect against the injury due to MCTP. These results suggest that toxic oxygen metabolites do not play an important role in the pathogenesis of MCTP-induced pulmonary injury.
- Research Organization:
- Michigan State Univ., East Lansing
- OSTI ID:
- 6292135
- Journal Information:
- J. Toxicol. Environ. Health; (United States), Journal Name: J. Toxicol. Environ. Health; (United States) Vol. 21:1-2; ISSN JTEHD
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550901* -- Pathology-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ALBUMINS
AMINES
ANIMALS
AZOLES
BETA DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CATALASE
CHELATING AGENTS
DAYS LIVING RADIOISOTOPES
DEFEROXAMINE
DMSO
ELECTRON CAPTURE RADIOISOTOPES
ELEMENTS
ENZYMES
HETEROCYCLIC COMPOUNDS
INJURIES
INTERMEDIATE MASS NUCLEI
IODINE 125
IODINE ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
LEUKOCYTES
LUNGS
MAMMALS
MATERIALS
NEUTROPHILS
NONMETALS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC SULFUR COMPOUNDS
ORGANS
OXIDOREDUCTASES
OXYGEN
PEROXIDASES
PROTEINS
PYRROLES
RADICALS
RADIOISOTOPES
RATS
RESPIRATORY SYSTEM
RODENTS
SULFOXIDES
TOXICITY
TRACER TECHNIQUES
VERTEBRATES
59 BASIC BIOLOGICAL SCIENCES
ALBUMINS
AMINES
ANIMALS
AZOLES
BETA DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CATALASE
CHELATING AGENTS
DAYS LIVING RADIOISOTOPES
DEFEROXAMINE
DMSO
ELECTRON CAPTURE RADIOISOTOPES
ELEMENTS
ENZYMES
HETEROCYCLIC COMPOUNDS
INJURIES
INTERMEDIATE MASS NUCLEI
IODINE 125
IODINE ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
LEUKOCYTES
LUNGS
MAMMALS
MATERIALS
NEUTROPHILS
NONMETALS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC SULFUR COMPOUNDS
ORGANS
OXIDOREDUCTASES
OXYGEN
PEROXIDASES
PROTEINS
PYRROLES
RADICALS
RADIOISOTOPES
RATS
RESPIRATORY SYSTEM
RODENTS
SULFOXIDES
TOXICITY
TRACER TECHNIQUES
VERTEBRATES