Effect of antiperoxidative drugs on gastric damage induced by ethanol in rats

Journal Article · Mon Aug 10 00:00:00 EDT 1987 · Life Sci.; (United States)

DOI:https://doi.org/10.1016/0024-3205(87)90456-5· OSTI ID:6290847

Mizui, T; Sato, H; Hirose, F; Doteuchi, M

Lesion formation due to oral administration of absolute ethanol could be prevented by parenteral pretreatment with antiperoxidative drugs such as butylated hydroxytoluene (BHT), quercetin and quinacrine. Also effective were allopurinol and oxypurinol, inhibitors of xanthine oxidase, but not superoxide dismutase (SOD) and hydroxyl radical scavengers, such as sodium benzoate and dimethyl sulfoxide (DMSO). BHT, quercetin, quinacrine and sulfhydryl compounds such as reduced glutathione and cysteamine which offer gastroprotection in vivo against ethanol inhibited lipid peroxidation induced in vitro by ferrous ion in porcine gastric mucosal homogenate, but SOD, sodium benzoate, DMSO, allopurinol and oxypurinol did not. These results suggest the possibility that an active species, probably derived from free iron mobilized by the xanthine oxidase system, other than oxygen radicals such as hydroxyl formation in the gastric mucosa after absolute ethanol administration. 38 references, 1 figure, 4 tables.

• Research Organization: Shionogi and Co., Ltd., Osaka, Japan
• OSTI ID: 6290847
• Journal Information: Life Sci.; (United States), Journal Name: Life Sci.; (United States) Vol. 41:6; ISSN LIFSA
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALCOHOLS
ANIMALS
CELL CONSTITUENTS
CELL MEMBRANES
DATA
DIGESTIVE SYSTEM
ETHANOL
EXPERIMENTAL DATA
GASTROINTESTINAL TRACT
HYDROXY COMPOUNDS
INFORMATION
LIPIDS
MAMMALS
MEMBRANES
METABOLISM
NUMERICAL DATA
ORAL ADMINISTRATION
ORGANIC COMPOUNDS
RATS
RESPONSE MODIFYING FACTORS
RODENTS
SENSITIVITY
TOXICITY
VERTEBRATES