Molecular biology of environmental aromatic hydrocarbons. Progress report, January 1-June 31, 1981

Technical Report · Wed Jul 01 04:00:00 EDT 1981

OSTI ID:6290460

Weiss, S B

We have been examining the molecular biology of activated polycyclic aromatic hydrocarbons (PAH) in several different ways, using different biochemical systems. The projects involving these systems are as follows: (I) The binding of benzo(a)pyrene-7,8-dihydrodiol to phage DNA; (II) the binding of PAH-epoxide derivatives to single- and double-stranded 0X174 DNA and its effect on viral DNA infectivity; (III) the fate of benzo(a)pyrene adducts on SV40 DNA in infected monkey kidney cells; (IV) the effect of PAH derivatives on RNA transcription; and (V) the effects of anti-BPDE on tRNA aminoacyl charging and protein synthesis.

• Research Organization: Chicago Univ., IL (USA)
• DOE Contract Number: AC02-80EV10328
• OSTI ID: 6290460
• Report Number(s): DOE/EV/10328-T1; ON: DE81029033
• Country of Publication: United States
• Language: English

Related Subjects

560301* -- Chemicals Metabolism & Toxicology-- Cells-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AROMATICS
BACTERIOPHAGES
BIOLOGICAL EFFECTS
BIOSYNTHESIS
DNA
HYDROCARBONS
INFECTIVITY
MICROORGANISMS
MOLECULAR BIOLOGY
NUCLEIC ACIDS
ORGANIC COMPOUNDS
PARASITES
POLYCYCLIC AROMATIC HYDROCARBONS
PROTEINS
RNA
SYNTHESIS
TRANSCRIPTION
VIRUSES