Measurement of phthalates in small samples of mammalian tissue
Journal Article
·
· Bull. Environ. Contam. Toxicol.; (United States)
Di-(2-ethylhexyl)-phthalate (DEHP) is a phthalic acid ester that is used as a plasticizer in polyvinyl chloride products, many of which have widespread medical application. DEHP has been shown to be leached from products used for storage and delivery of blood transfusions during procedures such as plasmaphoresis, hemodialysis and open heart surgery. Results of studies in this laboratory have suggested that there is an association between the absorption and deposition of DEHP (and/or related chemicals) in the kidney and the acquired renal cystic disease (ACD) frequently seen in patients who have undergone prolonged dialysis treatment. In order to determine the relationship between the two, it has been necessary to establish a method for extracting and accurately quantitating minute amounts of these chemicals in small tissue samples. The authors have now established such a method using kidneys from normal rats and from a rat model for ACD.
- Research Organization:
- Dalhousie Univ., Halifax, Nova Scotia
- OSTI ID:
- 6290436
- Journal Information:
- Bull. Environ. Contam. Toxicol.; (United States), Journal Name: Bull. Environ. Contam. Toxicol.; (United States) Vol. 38:3; ISSN BECTA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550601 -- Medicine-- Unsealed Radionuclides in Diagnostics
560300* -- Chemicals Metabolism & Toxicology
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL MODELS
BODY
CARBON 14 COMPOUNDS
CARBOXYLIC ACID SALTS
CHEMICAL ANALYSIS
CHROMATOGRAPHY
DIALYSIS
GAS CHROMATOGRAPHY
ISOTOPE APPLICATIONS
KIDNEYS
LABELLED COMPOUNDS
MAMMALS
MASS SPECTROSCOPY
ORGANS
PHARMACOLOGY
PHTHALATES
QUANTITATIVE CHEMICAL ANALYSIS
RATS
RODENTS
SEPARATION PROCESSES
SPECTROSCOPY
TRACER TECHNIQUES
VERTEBRATES
560300* -- Chemicals Metabolism & Toxicology
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL MODELS
BODY
CARBON 14 COMPOUNDS
CARBOXYLIC ACID SALTS
CHEMICAL ANALYSIS
CHROMATOGRAPHY
DIALYSIS
GAS CHROMATOGRAPHY
ISOTOPE APPLICATIONS
KIDNEYS
LABELLED COMPOUNDS
MAMMALS
MASS SPECTROSCOPY
ORGANS
PHARMACOLOGY
PHTHALATES
QUANTITATIVE CHEMICAL ANALYSIS
RATS
RODENTS
SEPARATION PROCESSES
SPECTROSCOPY
TRACER TECHNIQUES
VERTEBRATES