Effects of prolonged administration of phthalate ester on the liver

Journal Article · Sat Aug 01 04:00:00 EDT 1987 · Environ. Health Perspect.; (United States)

DOI:https://doi.org/10.1289/ehp.8773251· OSTI ID:6175654

Ganning, A E; Brunk, U; Edlund, C; Elhammer, A; Dallner, G

Di(2-ethylhexyl)phthalate (DEHP) was administered to male rats in the diet at concentrations of 2.0, 0.2, and 0.02% for up to 102 weeks. Low doses resulted in moderate increases in certain hepatic enzymes during the initial phase of exposure and in a continuous increase in the activities of these same enzymes throughout the treatment period. An increased level of dolichol and decreased concentration of dolichyl-P were observed. Furthermore, the rate of protein glycosylation diminished. Liver biopsies from patients subjected to hemodialysis demonstrated an increased number of peroxisomes. Phthalate ester seems to interfere with protein turnover, so that the half-life of total mitochondrial and microsomal protein is considerably increased.

• Research Organization: Univ. of Stockholm, Sweden
• OSTI ID: 6175654
• Journal Information: Environ. Health Perspect.; (United States), Journal Name: Environ. Health Perspect.; (United States) Vol. 73; ISSN EVHPA
• Country of Publication: United States
• Language: English

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59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINO ACIDS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOSYNTHESIS
BODY
CARBOXYLIC ACIDS
CHRONIC INTAKE
DAYS LIVING RADIOISOTOPES
DIALYSIS
DIGESTIVE SYSTEM
DRUGS
ELECTRON MICROSCOPY
ENZYME ACTIVITY
ENZYMES
ESTERS
EVEN-ODD NUCLEI
GLANDS
GLYCOSYL TRANSFERASES
INTAKE
ISOTOPES
LABELLED COMPOUNDS
LEUCINE
LIGHT NUCLEI
LIPOTROPIC FACTORS
LIVER
METHIONINE
MICROSCOPY
NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
ORGANS
PATIENTS
PHTHALIC ACID ESTERS
PROTEINS
RADIOISOTOPES
SEPARATION PROCESSES
SULFUR 35
SULFUR ISOTOPES
SYNTHESIS
TRANSFERASES
TRANSMISSION ELECTRON MICROSCOPY
TRITIUM COMPOUNDS