TCDD, dietary iron and hepatic iron distribution in female rats

Journal Article · Sun Feb 01 04:00:00 EST 1987 · Bull. Environ. Contam. Toxicol.; (United States)

DOI:https://doi.org/10.1007/BF01606678· OSTI ID:6290295

Al-Bayati, Z A.F.; Stohs, S J; Al-Turk, W A

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a prototype for a large group of halogenated aromatic hydrocarbons, and is the most potent of these compounds. TCDD is an environmental pollutant with exceptional toxicity for certain mammalian and avian species. The liver is one of the principal target organs affected by TCDD in the rat and other laboratory species. TCDD induces many functional, biochemical and pathological changes, including altered lipid metabolism in the liver. Ferrous iron plays an important role in the initiation of lipid peroxidation. A proposed mechanism for the production of liver injury in chronic iron overload is that organelle damage leading to cell death occurs as a result of membrane lipid peroxidation initiated and promoted by intracellular iron. The presence of iron in subcellular fractions in vitro may catalyze lipid peroxidation and produce membrane damage. There is evidence for the occurrence of hepatic lipid peroxidation after TCDD administration. The purpose of this study was to determine if TCDD induced lipid peroxidation was associated with an increase in the iron content of liver and its subcellular fractions. The effect of TCDD administration on the iron content of whole homogenate, microsomes, mitochondria, and cytosol of livers of female rats fed defined diets containing deficient, normal and excessive levels of iron for 17, 24 and 31 days was investigated.

• Research Organization: Univ. of Nebraska Medical Center, Omaha
• OSTI ID: 6290295
• Journal Information: Bull. Environ. Contam. Toxicol.; (United States), Journal Name: Bull. Environ. Contam. Toxicol.; (United States) Vol. 38:2; ISSN BECTA
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ABSORPTION SPECTROSCOPY
ANIMALS
AROMATICS
BIOLOGICAL EFFECTS
BODY
CELL CONSTITUENTS
CHEMICAL REACTIONS
CHLORINATED AROMATIC HYDROCARBONS
DIET
DIGESTIVE SYSTEM
DIOXIN
DISTRIBUTION
GLANDS
HALOGENATED AROMATIC HYDROCARBONS
HETEROCYCLIC COMPOUNDS
IRON COMPOUNDS
IRON SULFATES
LIPIDS
LIVER
MAMMALS
MICROSOMES
MITOCHONDRIA
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
ORGANOIDS
ORGANS
OXIDATION
OXYGEN COMPOUNDS
RATS
RODENTS
SPECTROSCOPY
SULFATES
SULFUR COMPOUNDS
TISSUE DISTRIBUTION
TRANSITION ELEMENT COMPOUNDS
VERTEBRATES