12-O-tetradecanoyl phorbol-13-acetate (TPA) stimulates somatostatin release from isolated perfused rat stomach

Journal Article · Tue Jan 01 00:00:00 EST 1985 · Life Sci.; (United States)

DOI:https://doi.org/10.1016/0024-3205(85)90109-2· OSTI ID:6289955

Yamatani, T; Kadowaki, S; Chiba, T; Chihara, K; Fukase, M; Fujita, T

Effect of TPA (12-O-tetradecanoyl phorbol-13-acetate), a potent tumor promoter, on immunoreactive somatostatin release was investigated using the isolated perfused rat stomach. TPA at the concentration as low as 20 nM significantly stimulated the somatostatin release from isolated perfused rat stomach. The integrated net output of somatostatin induced by TPA was dose-dependent in a range of 5 - 50nM TPA. Since TPA is known to activate C-kinase specifically at a low dose (<20nM), these findings suggest that C-kinase system may be involved in the regulation of somatostatin release in rat stomach. 14 references, 2 figures.

• Research Organization: Kobe Univ. School of Medicine, Japan
• OSTI ID: 6289955
• Journal Information: Life Sci.; (United States), Vol. 37:25
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
PHORBOL ESTERS
BIOLOGICAL EFFECTS
PHOSPHOTRANSFERASES
ENZYME ACTIVITY
SOMATOSTATIN
SECRETION
DOSE-RESPONSE RELATIONSHIPS
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STOMACH
ANIMALS
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DIGESTIVE SYSTEM
ENZYMES
ESTERS
GASTROINTESTINAL TRACT
INFORMATION
MAMMALS
NUMERICAL DATA
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ORGANS
PHOSPHORUS-GROUP TRANSFERASES
RODENTS
TRANSFERASES
VERTEBRATES
560305* - Chemicals Metabolism &amp; Toxicology- Vertebrates- (-1987)