12-O-tetradecanoyl phorbol-13-acetate (TPA) stimulates somatostatin release from isolated perfused rat stomach
Journal Article
·
· Life Sci.; (United States)
Effect of TPA (12-O-tetradecanoyl phorbol-13-acetate), a potent tumor promoter, on immunoreactive somatostatin release was investigated using the isolated perfused rat stomach. TPA at the concentration as low as 20 nM significantly stimulated the somatostatin release from isolated perfused rat stomach. The integrated net output of somatostatin induced by TPA was dose-dependent in a range of 5 - 50nM TPA. Since TPA is known to activate C-kinase specifically at a low dose (<20nM), these findings suggest that C-kinase system may be involved in the regulation of somatostatin release in rat stomach. 14 references, 2 figures.
- Research Organization:
- Kobe Univ. School of Medicine, Japan
- OSTI ID:
- 6289955
- Journal Information:
- Life Sci.; (United States), Journal Name: Life Sci.; (United States) Vol. 37:25; ISSN LIFSA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BODY
CARCINOGENS
DATA
DIGESTIVE SYSTEM
DOSE-RESPONSE RELATIONSHIPS
ENZYME ACTIVITY
ENZYMES
ESTERS
EXPERIMENTAL DATA
GASTROINTESTINAL TRACT
INFORMATION
MAMMALS
NUMERICAL DATA
ORGANIC COMPOUNDS
ORGANS
PHORBOL ESTERS
PHOSPHORUS-GROUP TRANSFERASES
PHOSPHOTRANSFERASES
RATS
RODENTS
SECRETION
SOMATOSTATIN
STOMACH
TRANSFERASES
VERTEBRATES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BODY
CARCINOGENS
DATA
DIGESTIVE SYSTEM
DOSE-RESPONSE RELATIONSHIPS
ENZYME ACTIVITY
ENZYMES
ESTERS
EXPERIMENTAL DATA
GASTROINTESTINAL TRACT
INFORMATION
MAMMALS
NUMERICAL DATA
ORGANIC COMPOUNDS
ORGANS
PHORBOL ESTERS
PHOSPHORUS-GROUP TRANSFERASES
PHOSPHOTRANSFERASES
RATS
RODENTS
SECRETION
SOMATOSTATIN
STOMACH
TRANSFERASES
VERTEBRATES