Indications for and limitations of bone scintigraphy in osteogenic sarcoma: a review of 55 patients

Journal Article · Tue Sep 01 04:00:00 EDT 1981 · Cancer; (United States)

DOI:https://doi.org/10.1002/1097-0142(19810901)48:5<1133::AID-CNCR2820480515>3.0.CO;2-H· OSTI ID:6289504

McKillop, J H; Etcubanas, E; Goris, M L

The value of radioisotope bone scanning at the time of presentation and serially during follow-up has been evaluated in 55 patients with biopsy-proven osteogenic sarcoma. Many of the patients studied were treated with adjuvant chemotherapy. Bone metastases were detected at presentation in only one patient and in a second patient, proximal extension of the primary tumor not evident on radiographs was demonstrated by the radioisotope technique. During follow-up, 20 patients experienced bone metastases and each had an abnormal bone scan. Eleven of these patients were asymptomatic for bone metastases at the time the scan became abnormal. Seven patients experienced bone metastases as their first site of tumor recurrence. The detection rate for soft tissue metastases was low, but the scan indicated stump recurrence in three patients. Although the yield is small, bone scanning is justified at presentation because the results may profoundly alter the management. During follow-up, routine bone scans are indicated in all patients, whether they have symptoms or not.

• Research Organization: Stanford Univ. Medical Center, CA
• OSTI ID: 6289504
• Journal Information: Cancer; (United States), Journal Name: Cancer; (United States) Vol. 48:5; ISSN CANCA
• Country of Publication: United States
• Language: English

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550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
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62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
COUNTING TECHNIQUES
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DIAGNOSTIC USES
DISEASES
ESTERS
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MEDICINE
METASTASES
NEOPLASMS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANIC PHOSPHORUS COMPOUNDS
ORGANS
OSTEOSARCOMAS
PATIENTS
PHOSPHONIC ACID ESTERS
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIONUCLIDE KINETICS
SARCOMAS
SCINTISCANNING
SKELETAL DISEASES
SKELETON
SURGERY
TECHNETIUM 99
TECHNETIUM ISOTOPES
USES
YEARS LIVING RADIOISOTOPES