Local control of osteogenic sarcoma by radiation and chemotherapy

Journal Article · Sun Jan 01 04:00:00 EST 1984 · Int. J. Radiat. Oncol., Biol. Phys.; (United States)

DOI:https://doi.org/10.1016/0360-3016(84)90409-7· OSTI ID:6847749

Caceres, E; Zaharia, M; Valdivia, S; Misad, O; de la Flor, J; Tejada, F; Zubrod, G

Sixteen patients with osteogenic sarcoma of limbs were treated with high dose methotrexate followed by leucovorin rescue, adriamycin and radiotherapy to the primary tumor. A post-treatment surgical biopsy was performed in 15 of the 16 patients. In 12 of 15 patients (80%), the follow-up biopsy was negative for active tumor. Complications of treatment were myelosuppression (16 cases), moist desquamation (13 cases), soft tissue necrosis (2 cases) local infection (2 cases), fibrosis (9 cases) and bone fracture (4 cases). The mean survival time in this group of patients was 712 days.

• Research Organization: Inst Nacional de Enfermedades Neoplasicas, Lima, Peru
• OSTI ID: 6847749
• Journal Information: Int. J. Radiat. Oncol., Biol. Phys.; (United States), Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Vol. 12:1; ISSN IOBPD
• Country of Publication: United States
• Language: English

Related Subjects

550603 -- Medicine-- External Radiation in Therapy-- (1980-)
560151* -- Radiation Effects on Animals-- Man
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANTI-INFECTIVE AGENTS
ANTIBIOTICS
ANTIMETABOLITES
ANTINEOPLASTIC DRUGS
BONE FRACTURES
CHEMOTHERAPY
CITROVORUM FACTOR
DISEASES
DOXORUBICIN
DRUGS
FIBROSIS
IMMUNOSUPPRESSION
INJURIES
MEDICINE
METHOTREXATE
NECROSIS
NEOPLASMS
NUCLEAR MEDICINE
OSTEOSARCOMAS
PATHOLOGICAL CHANGES
PATIENTS
RADIOINDUCTION
RADIOLOGY
RADIOTHERAPY
SARCOMAS
SIDE EFFECTS
SKELETAL DISEASES
THERAPY