Evaluation of the potential carcinogenicity of n-methyl-n'-nitro-n-nitrosoguanidine (70-25-7). Final report

Technical Report · Wed Jun 01 04:00:00 EDT 1988

OSTI ID:6288609

N-Methyl-N'-nitro-N-nitrosoguanidine is a probable human carcinogen, classified as weight-of-evidence Group B2 under the EPA Guidelines for Carcinogen Risk Assessment (US EPA, 1986a). Evidence on potential carcinogenicity from animal studies is Sufficient, and the evidence from human studies is No Data. The potency factor (F) for N-methyl-N'-nitro-N-nitrosoguanidine is estimated to be 54.7/(mg/kg/day), placing it in potency group 2 according to the CAG's methodology for evaluating potential carcinogens (US EPA, 1986b). Combining the weight-of-evidence group and the potency group, N-methyl-N'-nitro-N-nitrosoguanidine is assigned a MEDIUM hazard ranking for the purposes of reportable quantity (RQ) adjustment.

• Research Organization: Syracuse Research Corp., NY (United States)
• OSTI ID: 6288609
• Report Number(s): PB-93-196350/XAB; CNN: EPA-68-03-3112; EPA-68-03-3182
• Country of Publication: United States
• Language: English

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