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Antigen-primed helper T cell function in CBA/N mice is radiosensitive. [/sup 60/Co; /sup 137/Cs]

Journal Article · · J. Immunol.; (United States)
OSTI ID:6288221
;
CBA/N mice have an X-linked immunodeficiency that includes a deficient humoral response to sheep red blood cells (SRBC). In order to study the cellular mechanisms of this deficiency we have examined helper T cell function to SRBC in an adoptive transfer system by using 2 different sources of helper T cells. When thymocytes were used as the source of helper T cell precursors in an adoptive transfer system, CBA/N thymocytes were as effective as CBA/Ca thymocytes in inducing CBA/Ca bone marrow cells to develop into both direct and indirect anti-SRBC plaque-forming cells (PFC). However, when SRBC-primed, irradiated recipient mice were used as the source of helper T cells, primed and irradiated CBA/N recipiets developed significantly fewer direct and indirect anti-SRBC PFC than similarly treated CBA/CA recipients when reconstituted with CBA/Ca bone marrow cells and challenged with SRBC. We conclude that antigen-primed helper T cell function in CBA/N mice is radiosensitive. Possible reasons for this are evaluated and discussed.
Research Organization:
Univ. of Colorado Health Sciences Center, Denver, CO
OSTI ID:
6288221
Journal Information:
J. Immunol.; (United States), Journal Name: J. Immunol.; (United States) Vol. 127:2; ISSN JOIMA
Country of Publication:
United States
Language:
English

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Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKALI METAL ISOTOPES
ANIMAL CELLS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BIOLOGY
BLOOD
BLOOD CELLS
BODY FLUIDS
BONE MARROW CELLS
CESIUM 137
CESIUM ISOTOPES
COBALT 60
COBALT ISOTOPES
CONNECTIVE TISSUE CELLS
ELECTROMAGNETIC RADIATION
GAMMA RADIATION
GENETICS
IMMUNITY
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IONIZING RADIATIONS
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LEUKOCYTES
LYMPHOCYTES
MAMMALS
MATERIALS
MICE
MINUTES LIVING RADIOISOTOPES
NUCLEI
ODD-EVEN NUCLEI
ODD-ODD NUCLEI
RADIATION EFFECTS
RADIATIONS
RADIOISOTOPES
RADIOSENSITIVITY
RODENTS
SOMATIC CELLS
THYMOCYTES
VERTEBRATES
YEARS LIVING RADIOISOTOPES