Involvement of glutathione in the enhanced renal excretion of methyl mercury in CFW Swiss mice

Journal Article · Wed May 01 04:00:00 EDT 1985 · Toxicol. Appl. Pharmacol.; (United States)

DOI:https://doi.org/10.1016/0041-008X(85)90252-2· OSTI ID:6287382

Mulder, K M; Kostyniak, P J

The present studies attempted to identify the mechanism for the elevated urinary excretion rate for methyl mercury (MM) previously reported in CFW Swiss mice. Strain comparisons of factors which could conceivably influence renal excretion of MM were made. The biotransformation of MM to the inorganic form did not appear to play a significant role. No significant strain differences were observed in the distribution of MM between plasma and red cells under in vivo or in vitro conditions. A significant strain difference in plasma oxidized glutathione (GSSG) concentrations was observed. However, plasma concentrations of reduced glutathione (GSH), the form of glutathione (GS) which interacts with MM, did not significantly vary between the strains. The rate of total glutathione (TGS) excretion in urine was approximately 2-fold higher in CFW mice than in CBA/J mice. The significantly higher urinary GS excretion in CFW mice was accompanied by a 1.6-fold lower urinary gamma-glutamyltranspeptidase (gamma-GTP) activity in this strain.

• Research Organization: State Univ. of New York, Buffalo
• OSTI ID: 6287382
• Journal Information: Toxicol. Appl. Pharmacol.; (United States), Journal Name: Toxicol. Appl. Pharmacol.; (United States) Vol. 3; ISSN TXAPA
• Country of Publication: United States
• Language: English

Related Subjects

551001* -- Physiological Systems-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ANIMALS
BIOCHEMISTRY
BODY BURDEN
CHEMISTRY
CLEARANCE
DRUGS
ENZYMES
EXCRETION
GLUTATHIONE
ISOTOPE APPLICATIONS
ISOTOPES
MAMMALS
MERCURY COMPOUNDS
MERCURY ISOTOPES
METHYLMERCURY
MICE
ORGANIC COMPOUNDS
ORGANIC MERCURY COMPOUNDS
PEPTIDES
PHARMACOLOGY
POLYPEPTIDES
PROTEINS
RADIOPROTECTIVE SUBSTANCES
RODENTS
TRACER TECHNIQUES
TRANSFERASES
VERTEBRATES