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In vitro growth inhibition of mastitis causing bacteria by phenolics and metal chelators

Journal Article · · J. Dairy Sci.; (United States)
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Antimicrobial activities of three phenolic compounds and four metal chelators were tested at 0, 250, 500, and 1000 ppm in vitro against four major mastitis-causing bacteria, Streptococcus agalactiae, Staphylococcus aureus, Klebsiella pnuemoniae, and Escherichia coli. Overall, butylated hydroxyanisole and tert-butylhydroquinone showed the greatest antimicrobial activity. These phenolics were bactericidal at 250 to 500 ppm against all four bacteria tested. The butylated hydroxytoluene was bactericidal against the gram-positive bacteria but was ineffective against the coliforms. At 250 ppm, disodium ethylenediaminetetraacetic acid was bactericidal against the gram-positive bacteria but much less effective against the gram-negatives. However, diethylene-triaminepentaacetic acid was more growth inhibitory than ethylenediaminetetraacetic acid against the gram-negative bacteria and especially against Escherichia coli. All other compounds were generally much less effective or ineffective against all four microorganisms. Therefore, butylated hydroxyanisole, butylated hydroxytoluene, tert-butylhydroquinone, ethylenediaminetetraacetic acid, and diethylenetriaminepentaacetic acid may have practical implications in the prevention or treatment of bovine mastitis.

Research Organization:
Washington State Univ., Pullman
OSTI ID:
6285852
Journal Information:
J. Dairy Sci.; (United States), Journal Name: J. Dairy Sci.; (United States) Vol. 68:11; ISSN JDSCA
Country of Publication:
United States
Language:
English

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Related Subjects

560302* -- Chemicals Metabolism & Toxicology-- Microorganisms-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINO ACIDS
ANIMALS
ANTIOXIDANTS
AROMATICS
BACTERIA
BIOLOGICAL EFFECTS
BODY
CARBOXYLIC ACIDS
CATTLE
CHELATING AGENTS
COMPARATIVE EVALUATIONS
DISEASES
DOMESTIC ANIMALS
EDTA
ESCHERICHIA COLI
GLANDS
GROWTH
HYDROXY COMPOUNDS
IN VITRO
INFECTIOUS DISEASES
INHIBITION
KLEBSIELLA
MAMMALS
MAMMARY GLANDS
MICROORGANISMS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
PHENOLS
RUMINANTS
STAPHYLOCOCCUS
STREPTOCOCCUS
VERTEBRATES