Expert scientific judgment and cancer risk assessment: a pilot study of pharmacokinetic data

Journal Article · Thu Dec 01 04:00:00 EST 1988 · Risk Anal.; (United States)

DOI:https://doi.org/10.1111/j.1539-6924.1988.tb01205.x· OSTI ID:6277733

Hawkins, N C; Graham, J D

When high-dose tumor data are extrapolated to low doses, it is typically assumed that the dose of a carcinogen delivered to target cells is proportional to the dose administered to test animals, even at exposure levels below the experimental range. Since pharmacokinetic data are becoming available that in some cases question the validity of this assumption, risk assessors must decide whether to maintain the standard assumption. A pilot study of formaldehyde is reported that was undertaken to demonstrate how expert scientific judgment can help guide a controversial risk assessment where pharmacokinetic data are considered inconclusive. Eight experts on pharmacokinetic data were selected by a formal procedure, and each was interviewed personally using a structured interview protocol. The results suggest that expert scientific opinion is polarized in this case, a situation that risk assessors can respond to with a range of risk characterizations considered biologically plausible by the experts. Convergence of expert opinion is likely in this case if several specific research strategies are executed in a competent fashion. Elicitation of expert scientific judgment is a promising vehicle for evaluating the quality of pharmacokinetic data, expressing uncertainty in risk assessment, and fashioning a research agenda that offers possible forging of scientific consensus.

• Research Organization: Harvard School of Public Health, Boston, MA (USA)
• OSTI ID: 6277733
• Journal Information: Risk Anal.; (United States), Journal Name: Risk Anal.; (United States) Vol. 8:4; ISSN RIAND
• Country of Publication: United States
• Language: English

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