Possible mechanism for accelerated atherogenesis in male versus female rats

Journal Article · Wed Mar 01 04:00:00 EST 1989 · Arteriosclerosis (Dallas); (United States)

DOI:https://doi.org/10.1161/01.ATV.9.2.224· OSTI ID:6277079

Staprans, I; Felts, J M

Dietary fat and cholesterol enter the circulation as chylomicrons. They are removed from the circulation by attachment to lipoprotein lipase located on the endothelial surfaces. As the result of lipoprotein lipase action, chylomicrons are partially hydrolyzed and then reenter the circulation as remnants, which are rapidly cleared by the liver. We investigated the fate of /sup 3/H-retinol- and /sup 14/C-cholesterol-labeled chylomicrons injected into male and female rats. The disappearance curves of chylomicrons from the circulation were not significantly different in males and females, which suggests that translocation from plasma to endothelium is similar for both sexes. However, in male rats, the dwell time of chylomicrons on the endothelium was significantly prolonged. At 10 and 20 minutes after chylomicron injection, more label was found in the livers of female than male rats. The opposite was true for hearts. Male hearts contained significantly more endothelium-bound chylomicrons when compared with female hearts. This increase in dwell time may allow greater cholesterol deposition in the endothelium of male rats. The more rapid processing of chylomicrons was associated with a 300% greater postheparin lipoprotein lipase in female rats, which suggests a greater enzyme density at chylomicron attachment points on endothelium.

• Research Organization: VA Medical Center, San Francisco, CA (USA)
• OSTI ID: 6277079
• Journal Information: Arteriosclerosis (Dallas); (United States), Journal Name: Arteriosclerosis (Dallas); (United States) Vol. 9:2; ISSN ARTRD
• Country of Publication: United States
• Language: English

Related Subjects

550901* -- Pathology-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
AMINES
ANIMAL TISSUES
ANIMALS
ANTICOAGULANTS
ARTERIOSCLEROSIS
BODY
CARBOHYDRATES
CARBON 14 COMPOUNDS
CARBOXYLESTERASES
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
CHOLESTEROL
CHYLOMICRONS
DIGESTIVE SYSTEM
DISEASES
DRUGS
ENDOTHELIUM
ENZYME ACTIVITY
ENZYMES
ESTERASES
FATS
GLANDS
HEART
HEMATOLOGIC AGENTS
HEPARIN
HYDROLASES
HYDROXY COMPOUNDS
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
LIPASE
LIVER
MAMMALS
METABOLISM
MUCOPOLYSACCHARIDES
MUSCLES
MYOCARDIUM
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
ORGANS
PATHOGENESIS
POLYSACCHARIDES
RATS
RODENTS
SACCHARIDES
SEX DEPENDENCE
STEROIDS
STEROLS
TISSUES
TRACER TECHNIQUES
TRANSLOCATION
TRITIUM COMPOUNDS
VASCULAR DISEASES
VERTEBRATES
VITAMIN A
VITAMINS