Halogenated pyrimidines as radiosensitizers for high-LET radiation
Journal Article
·
· Radiat. Res.; (United States)
The incorporation of iododeoxyuridine (IdUrd) into Chinese hamster cells was examined as a possible radiosensitizer for fission spectrum neutrons. Dose-response curves comparing both X rays and neutrons in the same cell line with the same IdUrd replacement showed a similar radiation enhancement for IdUrd incorporation. Enhancement ratios at the 1% survival level were 1.8 for X rays and 1.5 for fission spectrum neutrons. While the mechanism of this enhancement in the response for fission neutron radiation is unclear, these positive data should support further exploration to determine if halogenated pyrimidine incorporation results in sensitization for neutron energies employed in therapy.
- Research Organization:
- National Cancer Institute, Bethesda, MD (USA)
- OSTI ID:
- 6276412
- Journal Information:
- Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 117:2; ISSN RAREA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560120* -- Radiation Effects on Biochemicals
Cells
& Tissue Culture
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANTIMETABOLITES
AZINES
BARYONS
CHO CELLS
DOSE-RESPONSE RELATIONSHIPS
DRUGS
ELECTROMAGNETIC RADIATION
ELEMENTARY PARTICLES
ENERGY TRANSFER
FERMIONS
FISSION NEUTRONS
HADRONS
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
IODODEOXYURIDINE
IODOURACILS
IONIZING RADIATIONS
LET
NEUTRONS
NUCLEONS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC IODINE COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PYRIMIDINES
RADIATIONS
RADIOSENSITIVITY EFFECTS
RADIOSENSITIZERS
RIBOSIDES
URACILS
X RADIATION
Cells
& Tissue Culture
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANTIMETABOLITES
AZINES
BARYONS
CHO CELLS
DOSE-RESPONSE RELATIONSHIPS
DRUGS
ELECTROMAGNETIC RADIATION
ELEMENTARY PARTICLES
ENERGY TRANSFER
FERMIONS
FISSION NEUTRONS
HADRONS
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
IODODEOXYURIDINE
IODOURACILS
IONIZING RADIATIONS
LET
NEUTRONS
NUCLEONS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC IODINE COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PYRIMIDINES
RADIATIONS
RADIOSENSITIVITY EFFECTS
RADIOSENSITIZERS
RIBOSIDES
URACILS
X RADIATION