Maximum recovery potential of human tumor cells may predict clinical outcome in radiotherapy
Journal Article
·
· Int. J. Radiat. Oncol., Biol. Phys.; (United States)
We studied inherent radiosensitivity/resistance (D0), ability to accumulate sublethal damage (n) and repair of potentially lethal damage (PLDR) in established human tumor cell lines as well as early passage human tumor cell lines derived from patients with known outcome following radiotherapy. Survival 24 hrs after treatment of human tumor cells with X rays in plateau phase cultures is a function of initial damage (D0, n), as well as recovery over 24 hrs (PLDR). A surviving fraction greater than .1 24 hrs following treatment with 7 Gy in plateau phase cultures is associated with tumor cell types (melanoma, osteosarcoma) with a high probability of radiotherapy failure or tumor cells derived from patients who actually failed radiotherapy. Therefore, total cellular recovery following radiation may be an important determinant of radiocurability. Accurate assays of radiotherapy outcome may need to account for all these radiobiological parameters.
- Research Organization:
- Michael Reese/Univ. of Chicago, IL
- OSTI ID:
- 6275553
- Journal Information:
- Int. J. Radiat. Oncol., Biol. Phys.; (United States), Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Vol. 5; ISSN IOBPD
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550603* -- Medicine-- External Radiation in Therapy-- (1980-)
560120 -- Radiation Effects on Biochemicals
Cells
& Tissue Culture
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
BIOLOGY
DISEASES
DNA REPAIR
ELECTROMAGNETIC RADIATION
INJURIES
IONIZING RADIATIONS
MEDICINE
MELANOMAS
NEOPLASMS
NUCLEAR MEDICINE
OSTEOSARCOMAS
PATIENTS
RADIATION EFFECTS
RADIATION INJURIES
RADIATIONS
RADIOBIOLOGY
RADIOLOGY
RADIOSENSITIVITY
RADIOTHERAPY
RECOVERY
REPAIR
SARCOMAS
SKELETAL DISEASES
SURVIVAL CURVES
THERAPY
TUMOR CELLS
X RADIATION
560120 -- Radiation Effects on Biochemicals
Cells
& Tissue Culture
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
BIOLOGY
DISEASES
DNA REPAIR
ELECTROMAGNETIC RADIATION
INJURIES
IONIZING RADIATIONS
MEDICINE
MELANOMAS
NEOPLASMS
NUCLEAR MEDICINE
OSTEOSARCOMAS
PATIENTS
RADIATION EFFECTS
RADIATION INJURIES
RADIATIONS
RADIOBIOLOGY
RADIOLOGY
RADIOSENSITIVITY
RADIOTHERAPY
RECOVERY
REPAIR
SARCOMAS
SKELETAL DISEASES
SURVIVAL CURVES
THERAPY
TUMOR CELLS
X RADIATION