Maximum recovery potential of human tumor cells may predict clinical outcome in radiotherapy
We studied inherent radiosensitivity/resistance (D0), ability to accumulate sublethal damage (n) and repair of potentially lethal damage (PLDR) in established human tumor cell lines as well as early passage human tumor cell lines derived from patients with known outcome following radiotherapy. Survival 24 hrs after treatment of human tumor cells with X rays in plateau phase cultures is a function of initial damage (D0, n), as well as recovery over 24 hrs (PLDR). A surviving fraction greater than .1 24 hrs following treatment with 7 Gy in plateau phase cultures is associated with tumor cell types (melanoma, osteosarcoma) with a high probability of radiotherapy failure or tumor cells derived from patients who actually failed radiotherapy. Therefore, total cellular recovery following radiation may be an important determinant of radiocurability. Accurate assays of radiotherapy outcome may need to account for all these radiobiological parameters.
- Research Organization:
- Michael Reese/Univ. of Chicago, IL
- OSTI ID:
- 6275553
- Journal Information:
- Int. J. Radiat. Oncol., Biol. Phys.; (United States), Vol. 5
- Country of Publication:
- United States
- Language:
- English
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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
RADIOTHERAPY
RADIOBIOLOGY
TUMOR CELLS
BIOLOGICAL REPAIR
RADIOSENSITIVITY
BIOLOGICAL RECOVERY
DNA REPAIR
MELANOMAS
NEOPLASMS
OSTEOSARCOMAS
PATIENTS
RADIATION INJURIES
SURVIVAL CURVES
X RADIATION
ANIMAL CELLS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOLOGY
DISEASES
ELECTROMAGNETIC RADIATION
INJURIES
IONIZING RADIATIONS
MEDICINE
NUCLEAR MEDICINE
RADIATION EFFECTS
RADIATIONS
RADIOLOGY
RECOVERY
REPAIR
SARCOMAS
SKELETAL DISEASES
THERAPY
550603* - Medicine- External Radiation in Therapy- (1980-)
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