Temporal analysis of myocardial glucose metabolism by 2-( sup 18 F)fluoro-2-deoxy-D-glucose
Journal Article
·
· American Journal of Physiology; (USA)
OSTI ID:6275139
- Univ. of Texas Health Science Center, Houston (USA)
To assess kinetic changes of myocardial glucose metabolism after physiological interventions, we perfused isolated working rat hearts with glucose and 2-(18F)fluoro-2-deoxy-D-glucose (2-FDG). Tissue uptake of 2-FDG and the input function were measured on-line by external detection. The fractional rate of 2-FDG phosphorylation was determined by graphical analysis of time-activity curves. The steady-state uptake of 2-FDG was linear with time, and the tracer was retained predominantly in its phosphorylated form. Tissue accumulation of 2-FDG decreased with a reduction in work load and with the addition of competing substrates. Insulin caused a significant increase in 2-FDG accumulation in hearts from fasted but not from fed animals. We conclude that in the isolated working rat heart there is rapid adjustment of exogenous substrate utilization and that most interventions known to alter glucose metabolism induce parallel changes in 2-FDG uptake. Qualitative differences in the in vitro response to insulin may be affected by the presence of either endogenous insulin or glycogen.
- OSTI ID:
- 6275139
- Journal Information:
- American Journal of Physiology; (USA), Journal Name: American Journal of Physiology; (USA) Vol. 259:4 Pt 2; ISSN 0002-9513; ISSN AJPHA
- Country of Publication:
- United States
- Language:
- English
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·
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· J. Nucl. Med.; (United States)
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· J. Nucl. Med.; (United States)
·
OSTI ID:5239994
Related Subjects
550501* -- Metabolism-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ALDEHYDES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BIOCHEMICAL REACTION KINETICS
BLOOD PRESSURE
BODY
CARBOHYDRATES
CARDIOVASCULAR SYSTEM
CHEMICAL REACTIONS
FLUORINE 18
FLUORINE ISOTOPES
GLUCOSE
HEART
HEXOSES
HORMONES
HOURS LIVING RADIOISOTOPES
INSULIN
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
KINETICS
LIGHT NUCLEI
MAMMALS
METABOLISM
MONOSACCHARIDES
MUSCLES
MYOCARDIUM
NUCLEI
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
ORGANS
PEPTIDE HORMONES
PHOSPHORYLATION
RADIOISOTOPES
RATS
REACTION KINETICS
RODENTS
SACCHARIDES
STEADY-STATE CONDITIONS
TRACER TECHNIQUES
VERTEBRATES
59 BASIC BIOLOGICAL SCIENCES
ALDEHYDES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BIOCHEMICAL REACTION KINETICS
BLOOD PRESSURE
BODY
CARBOHYDRATES
CARDIOVASCULAR SYSTEM
CHEMICAL REACTIONS
FLUORINE 18
FLUORINE ISOTOPES
GLUCOSE
HEART
HEXOSES
HORMONES
HOURS LIVING RADIOISOTOPES
INSULIN
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
KINETICS
LIGHT NUCLEI
MAMMALS
METABOLISM
MONOSACCHARIDES
MUSCLES
MYOCARDIUM
NUCLEI
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
ORGANS
PEPTIDE HORMONES
PHOSPHORYLATION
RADIOISOTOPES
RATS
REACTION KINETICS
RODENTS
SACCHARIDES
STEADY-STATE CONDITIONS
TRACER TECHNIQUES
VERTEBRATES