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Effects of spontaneously hypertensive rat plasma on blood pressure and tail artery calcium uptake in normotensive rats

Journal Article · · Am. J. Hypertens.; (United States)
OSTI ID:6268271
; ; ;
Previous studies have described the presence of humoral hypertensive factors in spontaneously hypertensive rats (SHR). Other studies have described factors that increase calcium uptake in vascular tissue. In this study, we attempted to confirm, and thereby correlate, the presence of both types of factors in SHR plasma. Intravenous infusion or bolus administration of dialyzed SHR plasma consistently induced an increase in blood pressure in normotensive rats. This hypertensive response was somewhat delayed, with peak blood pressures occurring /sup 45/ minutes after bolus administration and 90 minutes after infusion of SHR plasma. Spontaneously hypertensive rat plasma also increased /sup 45/Ca uptake in isolated normotensive rat tail arteries in a dose-dependent manner, with a time course similar to that for the hypertensive response to bolus administration. These findings suggest, therefore, that a substance exists in SHR plasma that can increase intracellular calcium in vascular tissues and thereby increase blood pressure.
Research Organization:
Univ. of Alberta, Edmonton (Canada)
OSTI ID:
6268271
Journal Information:
Am. J. Hypertens.; (United States), Journal Name: Am. J. Hypertens.; (United States) Vol. 2:1; ISSN AJHYE
Country of Publication:
United States
Language:
English

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Related Subjects

550901* -- Pathology-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ALKALINE EARTH ISOTOPES
ALKALINE EARTH METALS
ANIMALS
ARTERIES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD PLASMA
BLOOD PRESSURE
BLOOD VESSELS
BODY
BODY FLUIDS
CALCIUM
CALCIUM 45
CALCIUM ISOTOPES
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
DAYS LIVING RADIOISOTOPES
DISEASES
DOSE-RESPONSE RELATIONSHIPS
ELEMENTS
EVEN-ODD NUCLEI
HYPERTENSION
INTERMEDIATE MASS NUCLEI
ISOTOPE APPLICATIONS
ISOTOPES
MAMMALS
MATERIALS
METALS
NUCLEI
ORGANS
PATHOGENESIS
RADIOISOTOPES
RATS
RODENTS
SYMPTOMS
TRACER TECHNIQUES
UPTAKE
VASCULAR DISEASES
VERTEBRATES