Norepinephrine accumulation by the rat caudal artery in the presence of hypertensive plasma

Conference · Sat Mar 01 04:00:00 EST 1986 · Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States)

OSTI ID:5389936

Freas, W; Thompson, D A; Hart, J L; Muldoon, S M

We have partially isolated endogenous factors from canine plasma which inhibit /sup 3/H-norepinephrine (NE) accumulation by the canine saphenous vein. The purpose of this study is to determine if these circulating factors may account for the observed differences in /sup 3/H-NE uptake by hypertensive and normotensive blood vessels. Three models of hypertension were examined in this study. Blood vessels were compared from SHR and WKY rats, deoxycorticosterone acetate (DOCA) and control rats, and reduced renal mass (RRM) and control rats. There was no significant difference in /sup 3/H-NE accumulation between blood vessels obtained from RRM and paired control rats. However, both the SHR and DOCA hypertensive caudal arteries and aorta accumulated significantly more /sup 3/H-NE than their corresponding control tissues. There was not a significant change in /sup 3/H-NE accumulation between hypertensive and control vena cava and mesenteric arteries. Normotensive and hypertensive plasma inhibited /sup 3/H-NE accumulation by the rat caudal artery. However, there was not a correlation between blood pressure of plasma donor rats and accumulation of /sup 3/H-NE. Therefore, although there are differences in /sup 3/H-NE accumulation between hypertensive and normotensive blood vessels, plasma does not contain a factor responsible for this observed difference.

• OSTI ID: 5389936
• Report Number(s): CONF-8604222-
• Conference Information: Journal Name: Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States) Journal Volume: 45:3
• Country of Publication: United States
• Language: English

Related Subjects

550901* -- Pathology-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ADRENAL HORMONES
ANIMALS
ARTERIES
AUTONOMIC NERVOUS SYSTEM AGENTS
BIOLOGICAL ACCUMULATION
BIOLOGICAL MATERIALS
BIOLOGICAL MODELS
BIOLOGICAL VARIABILITY
BLOOD
BLOOD PLASMA
BLOOD PRESSURE
BLOOD VESSELS
BODY
BODY FLUIDS
CARDIOTONICS
CARDIOVASCULAR AGENTS
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
DISEASES
DOGS
DRUGS
HORMONES
HYPERTENSION
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
MAMMALS
MATERIALS
NEUROREGULATORS
NORADRENALINE
ORGANS
PATHOGENESIS
RATS
RODENTS
STEROID HORMONES
SYMPATHOMIMETICS
SYMPTOMS
TRACER TECHNIQUES
TRITIUM COMPOUNDS
VASCULAR DISEASES
VERTEBRATES