Norepinephrine accumulation by the rat caudal artery in the presence of hypertensive plasma

Conference · Sat Mar 01 00:00:00 EST 1986 · Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States)

OSTI ID:5389936

Freas, W; Thompson, D A; Hart, J L; Muldoon, S M

We have partially isolated endogenous factors from canine plasma which inhibit /sup 3/H-norepinephrine (NE) accumulation by the canine saphenous vein. The purpose of this study is to determine if these circulating factors may account for the observed differences in /sup 3/H-NE uptake by hypertensive and normotensive blood vessels. Three models of hypertension were examined in this study. Blood vessels were compared from SHR and WKY rats, deoxycorticosterone acetate (DOCA) and control rats, and reduced renal mass (RRM) and control rats. There was no significant difference in /sup 3/H-NE accumulation between blood vessels obtained from RRM and paired control rats. However, both the SHR and DOCA hypertensive caudal arteries and aorta accumulated significantly more /sup 3/H-NE than their corresponding control tissues. There was not a significant change in /sup 3/H-NE accumulation between hypertensive and control vena cava and mesenteric arteries. Normotensive and hypertensive plasma inhibited /sup 3/H-NE accumulation by the rat caudal artery. However, there was not a correlation between blood pressure of plasma donor rats and accumulation of /sup 3/H-NE. Therefore, although there are differences in /sup 3/H-NE accumulation between hypertensive and normotensive blood vessels, plasma does not contain a factor responsible for this observed difference.

• OSTI ID: 5389936
• Report Number(s): CONF-8604222-; TRN: 86-028518
• Journal Information: Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States), Vol. 45:3; Conference: 70. annual meeting of the Federation of American Society for Experimental Biology, St. Louis, MO, USA, 13 Apr 1986
• Country of Publication: United States
• Language: English

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HYPERTENSION
PATHOGENESIS
NORADRENALINE
BIOLOGICAL ACCUMULATION
ARTERIES
BIOLOGICAL MODELS
BIOLOGICAL VARIABILITY
BLOOD PLASMA
BLOOD PRESSURE
DOGS
RATS
TRACER TECHNIQUES
TRITIUM COMPOUNDS
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ANIMALS
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BLOOD
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BODY
BODY FLUIDS
CARDIOTONICS
CARDIOVASCULAR AGENTS
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
DISEASES
DRUGS
HORMONES
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
MAMMALS
MATERIALS
NEUROREGULATORS
ORGANS
RODENTS
STEROID HORMONES
SYMPATHOMIMETICS
SYMPTOMS
VASCULAR DISEASES
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