Clinical trials with hypoxic cell sensitizers: time to retrench or time to push forward
Journal Article
·
· Int. J. Radiat. Oncol., Biol. Phys.; (United States)
Results of world-wide clinical trials with misonidazole are discussed. An attempt is made to assess the reasons for the lack of positive results and the cost-benefit analysis is critically reviewed. The data on the clinical investigations of the second generation misonidazole analogues SR-2508 and RO-03-8799 are presented. Emphasis is placed on future work such as tumor selection for clinical trials, reduction of drug toxicity and methods to increase the drug radiosensitizing properties. Because of the large amount of knowledge, experience, productivity and good scientific clinical data accummulated with nitroimidazoles over the past five years, it is recommended that this is the time to push forward with the work on the newest, more efficient compounds.
- Research Organization:
- Univ. of Alberta and Cross Cancer Inst., Edmonton
- OSTI ID:
- 6264554
- Journal Information:
- Int. J. Radiat. Oncol., Biol. Phys.; (United States), Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Vol. 10:9; ISSN IOBPD
- Country of Publication:
- United States
- Language:
- English
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Sat Sep 01 00:00:00 EDT 1984
· Int. J. Radiat. Oncol., Biol. Phys.; (United States)
·
OSTI ID:6003191
Related Subjects
550603 -- Medicine-- External Radiation in Therapy-- (1980-)
560151* -- Radiation Effects on Animals-- Man
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANOXIA
ANTINEOPLASTIC DRUGS
AZOLES
BIOLOGICAL ACCUMULATION
BIOLOGICAL MATERIALS
BLOOD
BLOOD PLASMA
BODY
BODY FLUIDS
BRAIN
CENTRAL NERVOUS SYSTEM
DIGESTIVE SYSTEM
DISEASES
DRUGS
FRACTIONATED IRRADIATION
GLANDS
HETEROCYCLIC COMPOUNDS
IMIDAZOLES
IONIZING RADIATIONS
IRRADIATION
LIVER
LUNGS
MATERIALS
MEDICINE
METASTASES
MISONIDAZOLE
NEOPLASMS
NERVOUS SYSTEM
NUCLEAR MEDICINE
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
RADIATIONS
RADIOLOGY
RADIOSENSITIVITY EFFECTS
RADIOSENSITIZERS
RADIOTHERAPY
RESPIRATORY SYSTEM
SIDE EFFECTS
THERAPY
TOXICITY
560151* -- Radiation Effects on Animals-- Man
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANOXIA
ANTINEOPLASTIC DRUGS
AZOLES
BIOLOGICAL ACCUMULATION
BIOLOGICAL MATERIALS
BLOOD
BLOOD PLASMA
BODY
BODY FLUIDS
BRAIN
CENTRAL NERVOUS SYSTEM
DIGESTIVE SYSTEM
DISEASES
DRUGS
FRACTIONATED IRRADIATION
GLANDS
HETEROCYCLIC COMPOUNDS
IMIDAZOLES
IONIZING RADIATIONS
IRRADIATION
LIVER
LUNGS
MATERIALS
MEDICINE
METASTASES
MISONIDAZOLE
NEOPLASMS
NERVOUS SYSTEM
NUCLEAR MEDICINE
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
RADIATIONS
RADIOLOGY
RADIOSENSITIVITY EFFECTS
RADIOSENSITIZERS
RADIOTHERAPY
RESPIRATORY SYSTEM
SIDE EFFECTS
THERAPY
TOXICITY