Mechanisms of hypoxic cell radiosensitization and the development of new sensitizers
Journal Article
·
· Int. J. Radiat. Oncol., Biol. Phys.; (United States)
Some of the mechanisms by which drugs can potentiate the radiation response of tumors and cells in culture are discussed. Emphasis is placed on the action of nitroaromatic and heterocyclic compounds as hypoxic cell radiosensitizers, and some potential successors to misonidazole (MISO) are described. These include desmethylmisonidazole and SR 2508, selected because of their low toxicity in experimental systems. Groups of compounds, more efficient sensitizers than would be predicted from electron affinity correlations, have been examined and the use of Ro-03-8799 or RSU 1047 is proposed. Finally, ortho-substituted nitroimidazoles and electron-affinic compounds with alkylating groups are described. The latter group, in particular, holds promise for the development of compounds much superior to MISO.
- Research Organization:
- Inst. of Cancer Research, Sutton, England
- OSTI ID:
- 6721534
- Journal Information:
- Int. J. Radiat. Oncol., Biol. Phys.; (United States), Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Vol. 8:3/4; ISSN IOBPD
- Country of Publication:
- United States
- Language:
- English
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Fri Mar 31 23:00:00 EST 1989
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OSTI ID:6253742
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Thesis/Dissertation
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Thu Dec 31 23:00:00 EST 1987
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OSTI ID:5225261
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· Int. J. Radiat. Oncol., Biol. Phys.; (United States)
·
OSTI ID:5652626
Related Subjects
550603 -- Medicine-- External Radiation in Therapy-- (1980-)
560121 -- Radiation Effects on Cells-- External Source-- (-1987)
560301* -- Chemicals Metabolism & Toxicology-- Cells-- (-1987)
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AFFINITY
ALDEHYDES
ANIMAL CELLS
ANOXIA
ANTI-INFECTIVE AGENTS
ANTIBIOTICS
ANTIMITOTIC DRUGS
ANTINEOPLASTIC DRUGS
AZOLES
BIOCHEMISTRY
CARBOHYDRATES
CELL CULTURES
CHEMICAL PREPARATION
CHEMISTRY
DISEASES
DRUGS
GLUCOSE
HETEROCYCLIC COMPOUNDS
HEXOSES
IMIDAZOLES
MISONIDAZOLE
MITOMYCIN
MONOSACCHARIDES
NEOPLASMS
NITRO COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
RADIOSENSITIZERS
SACCHARIDES
SYNTHESIS
TOXICITY
TUMOR CELLS
560121 -- Radiation Effects on Cells-- External Source-- (-1987)
560301* -- Chemicals Metabolism & Toxicology-- Cells-- (-1987)
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AFFINITY
ALDEHYDES
ANIMAL CELLS
ANOXIA
ANTI-INFECTIVE AGENTS
ANTIBIOTICS
ANTIMITOTIC DRUGS
ANTINEOPLASTIC DRUGS
AZOLES
BIOCHEMISTRY
CARBOHYDRATES
CELL CULTURES
CHEMICAL PREPARATION
CHEMISTRY
DISEASES
DRUGS
GLUCOSE
HETEROCYCLIC COMPOUNDS
HEXOSES
IMIDAZOLES
MISONIDAZOLE
MITOMYCIN
MONOSACCHARIDES
NEOPLASMS
NITRO COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
RADIOSENSITIZERS
SACCHARIDES
SYNTHESIS
TOXICITY
TUMOR CELLS