In vivo method for the assessment of platelet accumulation
Journal Article
·
· J. Pharmacol. Methods; (United States)
Platelets labeled with 111-Indium have been injected intravenously into anesthetised guinea pigs, and intrathoracic content of 111-Indium-labeled platelets has been monitored continuously using a microcomputer-based system (AIMSplus). Dose-effect relationships have been described for ADP, collagen, and PAF, and effects of drugs upon selected responses illustrate the potential of this test system for routine in vivo screening of agents that may inhibit aggregation of platelets.
- Research Organization:
- Preclinical Research and Development, Basel (Switzerland)
- OSTI ID:
- 6257740
- Journal Information:
- J. Pharmacol. Methods; (United States), Journal Name: J. Pharmacol. Methods; (United States) Vol. 21:1; ISSN JPMED
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550201* -- Biochemistry-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ADP
ANIMALS
BETA DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BLOOD COAGULATION
BLOOD COAGULATION FACTORS
BLOOD PLATELETS
BODY FLUIDS
COAGULANTS
COLLAGEN
COMPUTERS
DAYS LIVING RADIOISOTOPES
DIGITAL COMPUTERS
DOSE-RESPONSE RELATIONSHIPS
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
ERYTHROCYTES
FIBRINOGEN
GLOBULINS
GUINEA PIGS
HEMATOLOGIC AGENTS
HEMOSTATICS
INDIUM 111
INDIUM ISOTOPES
INHIBITION
INJECTION
INTAKE
INTERMEDIATE MASS NUCLEI
INTRAVENOUS INJECTION
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPE DILUTION
ISOTOPES
MAMMALS
MATERIALS
MICROCOMPUTERS
MINUTES LIVING RADIOISOTOPES
NUCLEI
NUCLEOTIDES
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
PROTEINS
RADIOISOTOPES
RODENTS
SCLEROPROTEINS
SCREENING
TRACER TECHNIQUES
VERTEBRATES
59 BASIC BIOLOGICAL SCIENCES
ADP
ANIMALS
BETA DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BLOOD COAGULATION
BLOOD COAGULATION FACTORS
BLOOD PLATELETS
BODY FLUIDS
COAGULANTS
COLLAGEN
COMPUTERS
DAYS LIVING RADIOISOTOPES
DIGITAL COMPUTERS
DOSE-RESPONSE RELATIONSHIPS
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
ERYTHROCYTES
FIBRINOGEN
GLOBULINS
GUINEA PIGS
HEMATOLOGIC AGENTS
HEMOSTATICS
INDIUM 111
INDIUM ISOTOPES
INHIBITION
INJECTION
INTAKE
INTERMEDIATE MASS NUCLEI
INTRAVENOUS INJECTION
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPE DILUTION
ISOTOPES
MAMMALS
MATERIALS
MICROCOMPUTERS
MINUTES LIVING RADIOISOTOPES
NUCLEI
NUCLEOTIDES
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
PROTEINS
RADIOISOTOPES
RODENTS
SCLEROPROTEINS
SCREENING
TRACER TECHNIQUES
VERTEBRATES