Effect of iron dextran on ferritin content and T I-antiferritin localization in experimental hepatomas

Journal Article · · Cancer Drug Del.; (United States)

DOI:https://doi.org/10.1089/cdd.1985.2.3· OSTI ID:6257515

Rostock, R A; Kopher, K A; Bauer, T W; Klein, J L

Polyclonal T I rabbit antirat ferritin localizes in certain hepatoma models. The effect of intraperitoneal iron dextran on tumor and sera ferritin content and tumor and normal tissue localization with T I antiferritin was studied. Separate groups of 10-12 animals were injected with escalating doses of T I-antiferritin IgG, or nonspecific IgG, one week after injection with iron dextran or normal saline. The results demonstrate that tumor, serum, and normal tissue ferritin content was increased after iron dextran administration but tumor localization increased after administration of T I-antiferritin in the H4II-E and 7800 models. The 3924A and 7777 models showed no tumor localization with or without iron dextran but did show an increase in normal tissue localization after iron dextran. Immunoperoxidase staining of tissues with antiferritin revealed increased staining in the liver and spleen and only a slight increase in the tumors after iron dextran was administered. The results demonstrate that tumor localization is a complex phenomenon that depends on normal tissue, sera, and tumor-antigen distribution.

• Research Organization: Johns Hopkins Hospital, Baltimore, MD
• OSTI ID: 6257515
• Journal Information: Cancer Drug Del.; (United States), Journal Name: Cancer Drug Del.; (United States) Vol. 1; ISSN CDDED
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BLOOD SUBSTITUTES
CARBOHYDRATES
COMPLEXES
DAYS LIVING RADIOISOTOPES
DEXTRAN
DIAGNOSIS
DISEASES
DRUGS
FERRITIN
GLOBULINS
HEMATOLOGIC AGENTS
HEPATOMAS
IMMUNOGLOBULINS
IMMUNOLOGY
INTERMEDIATE MASS NUCLEI
IODINE 131
IODINE ISOTOPES
IRON COMPLEXES
IRON COMPOUNDS
ISOTOPE APPLICATIONS
ISOTOPES
MAMMALS
METALLOPROTEINS
NEOPLASMS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
POLYSACCHARIDES
PROTEINS
RADIOASSAY
RADIOIMMUNOASSAY
RADIOIMMUNOLOGY
RADIOISOTOPES
RATS
RODENTS
SACCHARIDES
TRACER TECHNIQUES
TRANSITION ELEMENT COMPLEXES
TRANSITION ELEMENT COMPOUNDS
VERTEBRATES