Noninvasive detection of coronary thrombi with /sup 111/In platelets: concise communication
The need for rapid, definitive identification of coronary thrombosis has been intensified by the advent of thrombolytic therapy and by interest in the role of thrombosis in the etiology of coronary artery disease. To determine whether platelet thrombi can be detected noninvasively with /sup 111/In platelets, a method was developed in which /sup 99m/Tc-tagged red blood cells were used to correct for activity within the blood attributable to platelets circulating but not associated with thrombus. In 18 dogs coronary thrombi were induced closed-chest with a copper coil introduced into the coronary artery. /sup 111/In platelets and /sup 99m/Tc RBCs were administered either before or 1 hr after induction of thrombus, and serial scintigrams obtained. Coronary thrombus was identified readily in the processed scintigrams. In six dogs, thrombolysis was achieved with intracoronary streptokinase. In each case serial scintigraphy demonstrated resolution of the clot. The dual radiotracer technique should permit serial noninvasive delineation of the temporal relationship between platelet deposition and coronary heart disease in patients, and should facilitate the evaluation of interventions designed to prevent platelet aggregation or to lyse existing thrombi.
- Research Organization:
- Washington University School of Medicine, St. Louis, Missouri
- OSTI ID:
- 6257343
- Journal Information:
- J. Nucl. Med.; (United States), Vol. 24:2
- Country of Publication:
- United States
- Language:
- English
Similar Records
Radioimmunoimaging of experimental thrombi in dogs using Tc-99m labeled monoclonal antibody fragments (MAPab-F(ab')/sub 2/) reactive with human platelets
Radioimmunoimaging of experimental thrombi in dogs using technetium-99m-labeled monoclonal antibody fragments reactive with human platelets
Related Subjects
CORONARIES
SCINTISCANNING
INDIUM 111
DIAGNOSTIC USES
TECHNETIUM 99
THROMBOSIS
DIAGNOSIS
BLOOD PLATELETS
DOGS
ERYTHROCYTES
HEART
ISOMERIC NUCLEI
LABELLED COMPOUNDS
STREPTOCOCCAL PROTEINASE
ANIMALS
ARTERIES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BLOOD VESSELS
BODY
BODY FLUIDS
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DISEASES
ELECTRON CAPTURE RADIOISOTOPES
ENZYMES
HOURS LIVING RADIOISOTOPES
HYDROLASES
INDIUM ISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
MATERIALS
MINUTES LIVING RADIOISOTOPES
NUCLEI
ODD-EVEN NUCLEI
ORGANS
PEPTIDE HYDROLASES
RADIOISOTOPE SCANNING
RADIOISOTOPES
SH-PROTEINASES
TECHNETIUM ISOTOPES
USES
VASCULAR DISEASES
VERTEBRATES
YEARS LIVING RADIOISOTOPES
550601* - Medicine- Unsealed Radionuclides in Diagnostics