Photocarcinogenesis by methoxypsoralen, neutral red, proflavine, and long UV radiation
A study of the photosensitizing effects of 8-methoxypsoralen (MOP), neutral red (NR), and proflavine (PF) on the skin of female Swiss albino mice, strain 955, was carried out using fractionated exposure to long ultraviolet light (300-400 nm) and visible light (tungsten emission). The results (1) confirmed MOP photocarcinogenicity, (2) demonstrated that both NR and PF are photocarcinogens, and, further, (3) showed that the above UV light with 2.6% of fluence at 313 nm is a long-term carcinogenic agent even though the total dose of 313 nm was 100 times less than the minimal UV tumorigenic dose in mice. The tumors were mammary adenocarcinomas, carcinomas of skin appendages, carcino-mixo-sarcomas, lymphomas, and one case of thyroid adenocarcinoma. The implications of the above data regarding the controversy about oncogenic risks in photochemotherapy are discussed.
- Research Organization:
- Univ. of Pavia, Italy
- OSTI ID:
- 6254509
- Journal Information:
- Cancer Detect. Prev.; (United States), Journal Name: Cancer Detect. Prev.; (United States) Vol. 4; ISSN CDPRD
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACRIDINES
AMINES
ANIMALS
ANTICOAGULANTS
AROMATICS
AZAARENES
AZINES
BODY
CARCINOMAS
COUMARINS
DISEASES
DRUGS
ELECTROMAGNETIC RADIATION
FLAVINES
HEMATOLOGIC AGENTS
HETEROCYCLIC COMPOUNDS
INDICATORS
LYMPHOMAS
MAMMALS
MICE
MUTAGENS
NEAR ULTRAVIOLET RADIATION
NEOPLASMS
NEUTRAL RED
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
ORGANS
PROFLAVINE
PSORALEN
PYRAZINES
PYRIDINES
RADIATIONS
RADIOINDUCTION
RADIOSENSITIVITY EFFECTS
RODENTS
SARCOMAS
SKIN
ULTRAVIOLET RADIATION
VERTEBRATES
VISIBLE RADIATION