Photocarcinogenesis by methoxypsoralen, neutral red, proflavine, and long UV radiation
A study of the photosensitizing effects of 8-methoxypsoralen (MOP), neutral red (NR), and proflavine (PF) on the skin of female Swiss albino mice, strain 955, was carried out using fractionated exposure to long ultraviolet light (300-400 nm) and visible light (tungsten emission). The results (1) confirmed MOP photocarcinogenicity, (2) demonstrated that both NR and PF are photocarcinogens, and, further, (3) showed that the above UV light with 2.6% of fluence at 313 nm is a long-term carcinogenic agent even though the total dose of 313 nm was 100 times less than the minimal UV tumorigenic dose in mice. The tumors were mammary adenocarcinomas, carcinomas of skin appendages, carcino-mixo-sarcomas, lymphomas, and one case of thyroid adenocarcinoma. The implications of the above data regarding the controversy about oncogenic risks in photochemotherapy are discussed.
- Research Organization:
- Univ. of Pavia, Italy
- OSTI ID:
- 6254509
- Journal Information:
- Cancer Detect. Prev.; (United States), Vol. 4
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
NEOPLASMS
RADIOINDUCTION
NEUTRAL RED
RADIOSENSITIVITY EFFECTS
PROFLAVINE
PSORALEN
ACRIDINES
CARCINOMAS
LYMPHOMAS
MICE
NEAR ULTRAVIOLET RADIATION
SARCOMAS
SKIN
VISIBLE RADIATION
AMINES
ANIMALS
ANTICOAGULANTS
AROMATICS
AZAARENES
AZINES
BODY
COUMARINS
DISEASES
DRUGS
ELECTROMAGNETIC RADIATION
FLAVINES
HEMATOLOGIC AGENTS
HETEROCYCLIC COMPOUNDS
INDICATORS
MAMMALS
MUTAGENS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
ORGANS
PYRAZINES
PYRIDINES
RADIATIONS
RODENTS
ULTRAVIOLET RADIATION
VERTEBRATES
560152* - Radiation Effects on Animals- Animals