Allelic association of human dopamine D sub 2 receptor gene in alcoholism

Journal Article · Wed Apr 18 04:00:00 EDT 1990 · JAMA, Journal of the American Medical Association; (USA)

DOI:https://doi.org/10.1001/jama.263.15.2055· OSTI ID:6253658

Blum, K; Sheridan, P J; Montgomery, A; Jagadeeswaran, P; Nogami, H; Briggs, A H ^[1]; Noble, E P; Ritchie, T; Cohn, J B ^[2]

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1. Univ. of Texas Health Science Center, San Antonio (USA)
2. Univ. of California, Los Angeles (USA)

In a blinded experiment, the authors report the first allelic association of the dopamine D{sub 2} receptor gene in alcoholism. From 70 brain samples of alcoholics and nonalcoholics, DNA was digested with restriction endonucleases and probed with a clone that contained the entire 3{prime} coding exon, the polyadenylation signal, and approximately 16.4 kilobases of noncoding 3{prime} sequence of the human dopamine D{sub 2} receptor gene ({lambda}hD2G1). In the present samples, the presence of A1 allele of the dopamine D{sub 2} receptor gene correctly classified 77% of alcoholics, and its absence classified 72% of nonalcoholics. The polymorphic pattern of this receptor gene suggests that a gene that confers susceptibility to at least one form of alcoholism is located on the q22-q23 region of chromosome 11.

• OSTI ID: 6253658
• Journal Information: JAMA, Journal of the American Medical Association; (USA), Journal Name: JAMA, Journal of the American Medical Association; (USA) Vol. 263:15; ISSN 0098-7484; ISSN JAMAA
• Country of Publication: United States
• Language: English

Related Subjects

550600* -- Medicine
62 RADIOLOGY AND NUCLEAR MEDICINE
ALCOHOLS
AMINES
AROMATICS
AUTONOMIC NERVOUS SYSTEM AGENTS
BIOLOGY
CARDIOTONICS
CARDIOVASCULAR AGENTS
CHROMOSOMES
DISEASES
DNA HYBRIDIZATION
DNA SEQUENCING
DNA-ASE
DOPAMINE
DRUGS
ENDONUCLEASES
ENZYMES
ESTERASES
GENES
GENETIC MAPPING
GENETICS
HETEROCHROMOSOMES
HYBRIDIZATION
HYDROLASES
HYDROXY COMPOUNDS
MAPPING
MEMBRANE PROTEINS
METABOLIC DISEASES
NEUROREGULATORS
ORGANIC COMPOUNDS
PHENOLS
PHOSPHODIESTERASES
POLYPHENOLS
PROTEINS
RECEPTORS
RFLPS
STRUCTURAL CHEMICAL ANALYSIS
SYMPATHOMIMETICS