No association between an allele at the D sub 2 dopamine receptor gene (DRD2) and alcoholism

Journal Article · Wed Oct 02 00:00:00 EDT 1991 · JAMA, Journal of the American Medical Association; (United States)

DOI:https://doi.org/10.1001/jama.1991.03470130081033· OSTI ID:5687048

Gelernter, J; Krystal, J; Kennedy, J L ^[1]; O'Malley, S; Risch, N; Merikangas, K; Kidd, K K ^[2]; Kranzler, H R ^[3]

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1. Yale Univ., New Haven, CT (United States) West Haven Dept. of Veterans Affairs Medical Center, CT (United States)
2. Yale Univ., New Haven, CT (United States)
3. Univ. of Connecticut, Farmington (United States)

The author attempted to replicate a positive allelic association between the A1 allele of DRD2 (the D{sub 2} dopamine receptor locus) and alcoholism that has been reported. They compared allele frequencies at the previously described Taq I restriction fragment length polymorphism system of DRD2 in alcoholics and random population controls.

• OSTI ID: 5687048
• Journal Information: JAMA, Journal of the American Medical Association; (United States), Vol. 266:13; ISSN 0098-7484
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
DOPAMINE
RECEPTORS
METABOLIC DISEASES
ETIOLOGY
RFLPS
GENETIC MAPPING
GENES
HUMAN POPULATIONS
MAN
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ANIMALS
AROMATICS
AUTONOMIC NERVOUS SYSTEM AGENTS
CARDIOTONICS
CARDIOVASCULAR AGENTS
DISEASES
DRUGS
HYDROXY COMPOUNDS
MAMMALS
MAPPING
MEMBRANE PROTEINS
NEUROREGULATORS
ORGANIC COMPOUNDS
PHENOLS
POLYPHENOLS
POPULATIONS
PRIMATES
PROTEINS
SYMPATHOMIMETICS
VERTEBRATES
550300* - Cytology