No association between an allele at the D sub 2 dopamine receptor gene (DRD2) and alcoholism

Journal Article · Wed Oct 02 04:00:00 EDT 1991 · JAMA, Journal of the American Medical Association; (United States)

DOI:https://doi.org/10.1001/jama.1991.03470130081033· OSTI ID:5687048

Gelernter, J; Krystal, J; Kennedy, J L ^[1]; O'Malley, S; Risch, N; Merikangas, K; Kidd, K K ^[2]; Kranzler, H R ^[3]

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1. Yale Univ., New Haven, CT (United States) West Haven Dept. of Veterans Affairs Medical Center, CT (United States)
2. Yale Univ., New Haven, CT (United States)
3. Univ. of Connecticut, Farmington (United States)

The author attempted to replicate a positive allelic association between the A1 allele of DRD2 (the D{sub 2} dopamine receptor locus) and alcoholism that has been reported. They compared allele frequencies at the previously described Taq I restriction fragment length polymorphism system of DRD2 in alcoholics and random population controls.

• OSTI ID: 5687048
• Journal Information: JAMA, Journal of the American Medical Association; (United States), Journal Name: JAMA, Journal of the American Medical Association; (United States) Vol. 266:13; ISSN 0098-7484; ISSN JAMAA
• Country of Publication: United States
• Language: English

Related Subjects

550300* -- Cytology
59 BASIC BIOLOGICAL SCIENCES
AMINES
ANIMALS
AROMATICS
AUTONOMIC NERVOUS SYSTEM AGENTS
CARDIOTONICS
CARDIOVASCULAR AGENTS
DISEASES
DOPAMINE
DRUGS
ETIOLOGY
GENES
GENETIC MAPPING
HUMAN POPULATIONS
HYDROXY COMPOUNDS
MAMMALS
MAN
MAPPING
MEMBRANE PROTEINS
METABOLIC DISEASES
NEUROREGULATORS
ORGANIC COMPOUNDS
PHENOLS
POLYPHENOLS
POPULATIONS
PRIMATES
PROTEINS
RECEPTORS
RFLPS
SYMPATHOMIMETICS
VERTEBRATES