The dopamine D sub 2 receptor locus as a modifying gene in neuropsychiatric disorders

Journal Article · Wed Oct 02 04:00:00 EDT 1991 · JAMA, Journal of the American Medical Association; (United States)

DOI:https://doi.org/10.1001/jama.266.13.1793· OSTI ID:5687539

Comings, D E; Comings, B G; Muhleman, D; Dietz, G; Shahbahrami, B; Tast, D; Knell, E; Kocsis, P; Baumgarten, R; Kovacs, B W; Gysin, R; Flanagan, S D ^[1]; Levy, D L ^[2]; Smith, M ^[3]; Klein, D N ^[4]; MacMurray, J; Tosk, J M ^[5]; Sverd, J ^[6]; Borison, R L; Evans, D D ^[7]

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1. City of Hope National Medical Center, Duarte, CA (United States)
2. McLean Hospital, Belmont, MA (United States)
3. Hillside Hospital, Glen Oaks, NY (United States)
4. State Univ. of New York, Stony Brook (United States)
5. Jerry L. Pettis Veterans Administration Hospital, Loma Linda, CA (United States)
6. North Shore Univ. Hospital, Manhasset, NY (United States) Cornell Univ. Medical College, Manhasset, NY (United States)
7. Veterans Administration Medical Center, Augusta, GA (United States)

The A1 allele of the Taq I polymorphism of the dopamine D{sub 2} receptor (DRD2) gene has been earlier reported to occur in 69% of alcoholics, compared with 20% of controls. Other research has reported no significant difference in the prevalence of the A1 allele in alcoholics vs controls and no evidence that the DRD2 gene was linked to alcoholism. The authors hypothesized that these seemingly conflicting results might be because increases in the prevalence of the A1 allele may not be specific to alcoholism. Thus, they examined other disorders frequently associated with alcoholism or those believed to involve defects in dopaminergic neurotransmission.

• OSTI ID: 5687539
• Journal Information: JAMA, Journal of the American Medical Association; (United States), Journal Name: JAMA, Journal of the American Medical Association; (United States) Vol. 266:13; ISSN 0098-7484; ISSN JAMAA
• Country of Publication: United States
• Language: English

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59 BASIC BIOLOGICAL SCIENCES
AMINES
ANIMAL CELLS
ANIMALS
AROMATICS
AUTONOMIC NERVOUS SYSTEM AGENTS
AUTORADIOGRAPHY
BIOELECTRICITY
CARDIOTONICS
CARDIOVASCULAR AGENTS
DISEASES
DNA HYBRIDIZATION
DOPAMINE
DRUGS
ELECTRICITY
GENES
HEREDITARY DISEASES
HYBRIDIZATION
HYDROXY COMPOUNDS
MAMMALS
MAN
MEMBRANE PROTEINS
MENTAL DISORDERS
METABOLIC DISEASES
NERVE CELLS
NEUROREGULATORS
ORGANIC COMPOUNDS
PHENOLS
POLYPHENOLS
PRIMATES
PROTEINS
RECEPTORS
RFLPS
SOMATIC CELLS
SYMPATHOMIMETICS
VERTEBRATES