The dopamine D sub 2 receptor locus as a modifying gene in neuropsychiatric disorders

Journal Article · Wed Oct 02 00:00:00 EDT 1991 · JAMA, Journal of the American Medical Association; (United States)

DOI:https://doi.org/10.1001/jama.266.13.1793· OSTI ID:5687539

Comings, D E; Comings, B G; Muhleman, D; Dietz, G; Shahbahrami, B; Tast, D; Knell, E; Kocsis, P; Baumgarten, R; Kovacs, B W; Gysin, R; Flanagan, S D ^[1]; Levy, D L ^[2]; Smith, M ^[3]; Klein, D N ^[4]; MacMurray, J; Tosk, J M ^[5]; Sverd, J ^[6]; Borison, R L; Evans, D D ^[7]

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1. City of Hope National Medical Center, Duarte, CA (United States)
2. McLean Hospital, Belmont, MA (United States)
3. Hillside Hospital, Glen Oaks, NY (United States)
4. State Univ. of New York, Stony Brook (United States)
5. Jerry L. Pettis Veterans Administration Hospital, Loma Linda, CA (United States)
6. North Shore Univ. Hospital, Manhasset, NY (United States) Cornell Univ. Medical College, Manhasset, NY (United States)
7. Veterans Administration Medical Center, Augusta, GA (United States)

The A1 allele of the Taq I polymorphism of the dopamine D{sub 2} receptor (DRD2) gene has been earlier reported to occur in 69% of alcoholics, compared with 20% of controls. Other research has reported no significant difference in the prevalence of the A1 allele in alcoholics vs controls and no evidence that the DRD2 gene was linked to alcoholism. The authors hypothesized that these seemingly conflicting results might be because increases in the prevalence of the A1 allele may not be specific to alcoholism. Thus, they examined other disorders frequently associated with alcoholism or those believed to involve defects in dopaminergic neurotransmission.

• OSTI ID: 5687539
• Journal Information: JAMA, Journal of the American Medical Association; (United States), Vol. 266:13; ISSN 0098-7484
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
DOPAMINE
RECEPTORS
GENES
AUTORADIOGRAPHY
BIOELECTRICITY
DNA HYBRIDIZATION
HEREDITARY DISEASES
MAN
MENTAL DISORDERS
METABOLIC DISEASES
NERVE CELLS
RFLPS
AMINES
ANIMAL CELLS
ANIMALS
AROMATICS
AUTONOMIC NERVOUS SYSTEM AGENTS
CARDIOTONICS
CARDIOVASCULAR AGENTS
DISEASES
DRUGS
ELECTRICITY
HYBRIDIZATION
HYDROXY COMPOUNDS
MAMMALS
MEMBRANE PROTEINS
NEUROREGULATORS
ORGANIC COMPOUNDS
PHENOLS
POLYPHENOLS
PRIMATES
PROTEINS
SOMATIC CELLS
SYMPATHOMIMETICS
VERTEBRATES
550201* - Biochemistry- Tracer Techniques