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Effect of gastrointestinal hormones on the pertechnetate imaging of ectopic gastric mucosa in experimental Meckel's diverticulum. [Dogs]

Journal Article · · J. Nucl. Med.; (United States)
OSTI ID:6252546
; ; ;
Meckel's diverticula were simulated in 12 dogs by implanting vascularized patches of gastric wall onto Roux-en-Y loops of distal ileum. All animals had camera imaging studies every 10 min for 60 min, with computer acquisition following intravenous injection of 2 mCi of pertechnetate. The scintigrams were repeated following (a) subcutaneous injection of pentagastrin 15 min before injection of pertechnetate; (b) intravenous injection of glucagon 10 min after the tracer injection; (c) pretreatment with pentagastrin plus glucagon as above; and (d) pretreatment with pentagastrin plus secretin. Pentagastrin alone accelerated accumulation of the tracer but resulted in a decrease in the target-to-background ratio. Glucagon alone enhanced late gastric mucosal activity by preventing washout of the intraluminal activity. The combination of pentagastrin and glucagon enhanced visualization and kept background activity lowest. These findgings indicate a potential role for glucagon in the diagnosis of ectopic gastric mucosa in humans.
Research Organization:
Ohio State Univ., Columbus
OSTI ID:
6252546
Journal Information:
J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 22:8; ISSN JNMEA
Country of Publication:
United States
Language:
English

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Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
COMPUTER CALCULATIONS
COUNTING TECHNIQUES
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DIGESTIVE SYSTEM
DIGESTIVE SYSTEM DISEASES
DISEASES
DOGS
GASTRIN
GASTROINTESTINAL TRACT
GLUCAGON
HORMONES
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
MEMBRANES
MUCOUS MEMBRANES
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
OXYGEN COMPOUNDS
PEPTIDE HORMONES
PEPTIDES
PERTECHNETATES
POLYPEPTIDES
PROTEINS
RADIOISOTOPE SCANNING
RADIOISOTOPES
SCINTISCANNING
SECRETIN
TECHNETIUM 99
TECHNETIUM COMPOUNDS
TECHNETIUM ISOTOPES
TRANSITION ELEMENT COMPOUNDS
VERTEBRATES
YEARS LIVING RADIOISOTOPES