Thyroid-hormone concentrations after radioiodine therapy for hyperthyroidism

Journal Article · Tue May 01 00:00:00 EDT 1979 · J. Nucl. Med.; (United States)

OSTI ID:6252352

Tamagna, E I; Levine, G A; Hershman, J M

Fourteen hyperthyroid patients (11 men, three women), ages 28 to 66, were followed with serial measurements of serum thyroid hormone levels for 1 mo after therapy with I-131. Twelve patients had diffuse toxic goiters (25 to 70 g in size); two patients had multinodular glands (40 to 100 g). The patients were taking no antithyroid medications; ten patients were treated with propranolol. All patients received the equivalent of 5000 rad, except the two with multinodular glands, who received larger doses. There was no consistent pattern of serum T/sub 4/ and T/sub 3/ levels after the I-131 therapy. For the entire group, there was no significant increase of the mean serum hormone concentration. One group (three patients) had a mean T/sub 4/ increase of 28% and a T/sub 3/ increase of 91% above baseline at Days 10--11. Seven patients had minimal increases of hormone levels at Days 2--3, and a third group (four paients) had no increase of thyroid hormones after I-131 therapy. The patients with no rise in hormone concentrations had smaller goiters than the other groups. There was no correlation of the dose of radioactive iodine, or of the initial hormone concentration, with the rises or declines of T/sub 4/ and T/sub 3/ levels after I-131 therapy. Radioiodine therapy caused no significant increase of serum T/sub 4/ and T/sub 3/ concentrations in the majority of patients.

• Research Organization: Univ. of California, Los Angeles
• OSTI ID: 6252352
• Journal Information: J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 20:5; ISSN JNMEA
• Country of Publication: United States
• Language: English

Related Subjects

550601 -- Medicine-- Unsealed Radionuclides in Diagnostics
550604 -- Medicine-- Unsealed Radionuclides in Therapy-- (1980-)
550901 -- Pathology-- Tracer Techniques
551001 -- Physiological Systems-- Tracer Techniques
560161* -- Radionuclide Effects
Kinetics
& Toxicology-- Man
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINO ACIDS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BLOOD SERUM
BODY
CARBOXYLIC ACIDS
DAYS LIVING RADIOISOTOPES
DISEASES
ENDOCRINE DISEASES
ENDOCRINE GLANDS
GLANDS
HORMONES
HYPERTHYROIDISM
INTERMEDIATE MASS NUCLEI
INTERNAL IRRADIATION
IODINE 131
IODINE ISOTOPES
IRRADIATION
ISOTOPE APPLICATIONS
ISOTOPES
LOCAL IRRADIATION
MEDICINE
NUCLEAR MEDICINE
NUCLEI
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC IODINE COMPOUNDS
ORGANS
PATIENTS
PEPTIDE HORMONES
RADIATION EFFECTS
RADIOASSAY
RADIOIMMUNOASSAY
RADIOISOTOPES
RADIOLOGY
RADIOTHERAPY
SIDE EFFECTS
THERAPY
THYROID
THYROID HORMONES
THYROXINE
TRACER TECHNIQUES
TRIIODOTHYRONINE