Responses of animals inhaling nitrogen dioxide for single, short-term exposures

Journal Article · Mon Jan 01 04:00:00 EST 1962 · Am. Ind. Hyg. Assoc. J.; (United States)

DOI:https://doi.org/10.1080/00028896209342900· OSTI ID:6251909

Carson, T R; Rosenholtz, M S; Wilinski, F T; Weeks, M H

Exposure of young rats, dogs, and rabbits to varying concentrations of NO/sub 2/ is discussed. LC/sub 50/ (death within 30 min to 3 days) decreased with increasing time: 415 ppM for 5 min or 115 ppM for 60 min for rats. Exposure of rats to approx. 50% of LC/sub 50/ produced respiratory distress and eye irritation lasting two days but no deaths. Exposure to 25% of LC/sub 50/ produced some distress which disappeared within an hour after exposure. Less effects in dogs with no pathologic changes was observed. Apparent threshold for lung-body weight ratio changes in rats is 104, 65, and 28 ppM NO/sub 2/ for 5-, 15-, and 60-min exposure, respectively.

• OSTI ID: 6251909
• Journal Information: Am. Ind. Hyg. Assoc. J.; (United States), Journal Name: Am. Ind. Hyg. Assoc. J.; (United States) Vol. 23; ISSN AIHAA
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BODY
CHALCOGENIDES
DISEASES
DOGS
EYES
MAMMALS
NITROGEN COMPOUNDS
NITROGEN DIOXIDE
NITROGEN OXIDES
ORGANS
OXIDES
OXYGEN COMPOUNDS
PATHOLOGY
RABBITS
RATS
RESPIRATORY SYSTEM DISEASES
RODENTS
SENSE ORGANS
VERTEBRATES